Inhibitory control in children with agenesis of the corpus callosum compared with typically developing children

Emilyn Soon; Vanessa Siffredi; Peter J Anderson; Vicki A Anderson; Alissandra McIlroy; Richard J Leventer; Amanda G Wood; Megan M Spencer-Smith

doi:10.1017/S1355617723000218

Inhibitory control in children with agenesis of the corpus callosum compared with typically developing children

Emilyn Soon
, Vanessa Siffredi
, Peter J Anderson
, Vicki A Anderson
, Alissandra McIlroy
, Richard J Leventer
, Amanda G Wood
, Megan M Spencer-Smith

Brain and Mind Research, Clinical Sciences Murdoch Children's Research Institute Melbourne Australia; Turner Institute for Brain and Mental Health, School of Psychological Sciences Monash University Melbourne Australia
Medical Image Processing Lab, Institute of Bioengineering, Center for Neuroprosthetics Ecole Polytechnique Fédérale de Lausanne Lausanne, VD Switzerland; Department of Radiology and Medical Informatics, Faculty of Medicine University of Geneva, Geneva Geneva Switzerland; CIBM Center for Biomedical Imaging Switzerland
Department of Paediatrics, University of Melbourne, Melbourne, Victoria 3010, Australia,Department of Neurology, Royal Children’s Hospital, Melbourne, Victoria 3052, Australia,Neuroscience Research, Clinical Sciences, Murdoch Children's Research Institute, Melbourne, Victoria 3052, Australia
Department of Neuroscience, Central Clinical School, Monash University, Melbourne, Australia.
Clinical Sciences, Murdoch Children's Research Institute, Parkville, Victoria, Australia.

Research output: Contribution to journal › Article › peer-review

3 Citations (Scopus)

23 Downloads (Pure)

Abstract

OBJECTIVES: The developmental absence (agenesis) of the corpus callosum (AgCC) is a congenital brain malformation associated with risk for a range of neuropsychological difficulties. Inhibitory control outcomes, including interference control and response inhibition, in children with AgCC are unclear. This study examined interference control and response inhibition: 1) in children with AgCC compared with typically developing (TD) children, 2) in children with different anatomical features of AgCC (complete vs. partial, isolated vs. complex), and 3) associations with white matter volume and microstructure of the anterior (AC) and posterior commissures (PC) and any remnant corpus callosum (CC).

METHODS: Participants were 27 children with AgCC and 32 TD children 8-16 years who completed inhibitory control assessments and brain MRI to define AgCC anatomical features and measure white matter volume and microstructure.

RESULTS: The AgCC cohort had poorer performance and higher rates of below average performance on inhibitory control measures than TD children. Children with complex AgCC had poorer response inhibition performance than children with isolated AgCC. While not statistically significant, there were select medium to large effect sizes for better inhibitory control associated with greater volume and microstructure of the AC and PC, and with reduced volume and microstructure of the remnant CC in partial AgCC.

CONCLUSIONS: This study provides evidence of inhibitory control difficulties in children with AgCC. While the sample was small, the study found preliminary evidence that the AC ( f 2=.18) and PC ( f 2=.30) may play a compensatory role for inhibitory control outcomes in the absence of the CC.

Original language	English
Pages (from-to)	1-9
Number of pages	9
Journal	Journal of the International Neuropsychological Society : JINS
Early online date	14 Apr 2023
DOIs	https://doi.org/10.1017/S1355617723000218
Publication status	E-pub ahead of print - 14 Apr 2023

Bibliographical note

This is an Open Access article, distributed under the terms of the Creative Commons Attribution licence (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted re-use, distribution, and reproduction in any medium, provided the original work is properly cited.

Copyright © INS. Published by Cambridge University Press, 2023

Keywords

executive functions
callosal agenesis
interference control
response inhibition
children
inhibition

Access to Document

10.1017/S1355617723000218Licence: CC BY 4.0

inhibitory-control-in-children-with-agenesis-of-the-corpus-callosum-compared-with-typically-developing-children
This is an Open Access article, distributed under the terms of the Creative Commons Attribution licence (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted re-use, distribution, and reproduction in any medium, provided the original work is properly cited. Copyright © INS. Published by Cambridge University Press, 2023
Final published version, 234 KBLicence: CC BY 4.0

Cite this

Soon, E., Siffredi, V., Anderson, P. J., Anderson, V. A., McIlroy, A., Leventer, R. J., Wood, A. G., & Spencer-Smith, M. M. (2023). Inhibitory control in children with agenesis of the corpus callosum compared with typically developing children. Journal of the International Neuropsychological Society : JINS, 1-9. Advance online publication. https://doi.org/10.1017/S1355617723000218

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title = "Inhibitory control in children with agenesis of the corpus callosum compared with typically developing children",

abstract = "OBJECTIVES: The developmental absence (agenesis) of the corpus callosum (AgCC) is a congenital brain malformation associated with risk for a range of neuropsychological difficulties. Inhibitory control outcomes, including interference control and response inhibition, in children with AgCC are unclear. This study examined interference control and response inhibition: 1) in children with AgCC compared with typically developing (TD) children, 2) in children with different anatomical features of AgCC (complete vs. partial, isolated vs. complex), and 3) associations with white matter volume and microstructure of the anterior (AC) and posterior commissures (PC) and any remnant corpus callosum (CC). METHODS: Participants were 27 children with AgCC and 32 TD children 8-16 years who completed inhibitory control assessments and brain MRI to define AgCC anatomical features and measure white matter volume and microstructure.RESULTS: The AgCC cohort had poorer performance and higher rates of below average performance on inhibitory control measures than TD children. Children with complex AgCC had poorer response inhibition performance than children with isolated AgCC. While not statistically significant, there were select medium to large effect sizes for better inhibitory control associated with greater volume and microstructure of the AC and PC, and with reduced volume and microstructure of the remnant CC in partial AgCC.CONCLUSIONS: This study provides evidence of inhibitory control difficulties in children with AgCC. While the sample was small, the study found preliminary evidence that the AC ( f 2=.18) and PC ( f 2=.30) may play a compensatory role for inhibitory control outcomes in the absence of the CC. ",

keywords = "executive functions, callosal agenesis, interference control, response inhibition, children, inhibition",

author = "Emilyn Soon and Vanessa Siffredi and Anderson, \{Peter J\} and Anderson, \{Vicki A\} and Alissandra McIlroy and Leventer, \{Richard J\} and Wood, \{Amanda G\} and Spencer-Smith, \{Megan M\}",

note = "This is an Open Access article, distributed under the terms of the Creative Commons Attribution licence (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted re-use, distribution, and reproduction in any medium, provided the original work is properly cited. Copyright {\textcopyright} INS. Published by Cambridge University Press, 2023",

year = "2023",

month = apr,

day = "14",

doi = "10.1017/S1355617723000218",

language = "English",

pages = "1--9",

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TY - JOUR

T1 - Inhibitory control in children with agenesis of the corpus callosum compared with typically developing children

AU - Soon, Emilyn

AU - Siffredi, Vanessa

AU - Anderson, Peter J

AU - Anderson, Vicki A

AU - McIlroy, Alissandra

AU - Leventer, Richard J

AU - Wood, Amanda G

AU - Spencer-Smith, Megan M

N1 - This is an Open Access article, distributed under the terms of the Creative Commons Attribution licence (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted re-use, distribution, and reproduction in any medium, provided the original work is properly cited. Copyright © INS. Published by Cambridge University Press, 2023

PY - 2023/4/14

Y1 - 2023/4/14

N2 - OBJECTIVES: The developmental absence (agenesis) of the corpus callosum (AgCC) is a congenital brain malformation associated with risk for a range of neuropsychological difficulties. Inhibitory control outcomes, including interference control and response inhibition, in children with AgCC are unclear. This study examined interference control and response inhibition: 1) in children with AgCC compared with typically developing (TD) children, 2) in children with different anatomical features of AgCC (complete vs. partial, isolated vs. complex), and 3) associations with white matter volume and microstructure of the anterior (AC) and posterior commissures (PC) and any remnant corpus callosum (CC). METHODS: Participants were 27 children with AgCC and 32 TD children 8-16 years who completed inhibitory control assessments and brain MRI to define AgCC anatomical features and measure white matter volume and microstructure.RESULTS: The AgCC cohort had poorer performance and higher rates of below average performance on inhibitory control measures than TD children. Children with complex AgCC had poorer response inhibition performance than children with isolated AgCC. While not statistically significant, there were select medium to large effect sizes for better inhibitory control associated with greater volume and microstructure of the AC and PC, and with reduced volume and microstructure of the remnant CC in partial AgCC.CONCLUSIONS: This study provides evidence of inhibitory control difficulties in children with AgCC. While the sample was small, the study found preliminary evidence that the AC ( f 2=.18) and PC ( f 2=.30) may play a compensatory role for inhibitory control outcomes in the absence of the CC.

AB - OBJECTIVES: The developmental absence (agenesis) of the corpus callosum (AgCC) is a congenital brain malformation associated with risk for a range of neuropsychological difficulties. Inhibitory control outcomes, including interference control and response inhibition, in children with AgCC are unclear. This study examined interference control and response inhibition: 1) in children with AgCC compared with typically developing (TD) children, 2) in children with different anatomical features of AgCC (complete vs. partial, isolated vs. complex), and 3) associations with white matter volume and microstructure of the anterior (AC) and posterior commissures (PC) and any remnant corpus callosum (CC). METHODS: Participants were 27 children with AgCC and 32 TD children 8-16 years who completed inhibitory control assessments and brain MRI to define AgCC anatomical features and measure white matter volume and microstructure.RESULTS: The AgCC cohort had poorer performance and higher rates of below average performance on inhibitory control measures than TD children. Children with complex AgCC had poorer response inhibition performance than children with isolated AgCC. While not statistically significant, there were select medium to large effect sizes for better inhibitory control associated with greater volume and microstructure of the AC and PC, and with reduced volume and microstructure of the remnant CC in partial AgCC.CONCLUSIONS: This study provides evidence of inhibitory control difficulties in children with AgCC. While the sample was small, the study found preliminary evidence that the AC ( f 2=.18) and PC ( f 2=.30) may play a compensatory role for inhibitory control outcomes in the absence of the CC.

KW - executive functions

KW - callosal agenesis

KW - interference control

KW - response inhibition

KW - children

KW - inhibition

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U2 - 10.1017/S1355617723000218

DO - 10.1017/S1355617723000218

M3 - Article

C2 - 37057871

SN - 1469-7661

SP - 1

EP - 9

JO - Journal of the International Neuropsychological Society : JINS

JF - Journal of the International Neuropsychological Society : JINS

ER -

Inhibitory control in children with agenesis of the corpus callosum compared with typically developing children

Abstract

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Keywords

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