Innate immunity and apoptosis: CD14-dependent clearance of apoptotic cells

Christopher D. Gregory, Andrew Devitt

Research output: Chapter in Book/Report/Conference proceedingChapter (peer-reviewed)

Abstract

This is the first comprehensive book about the relationship between apoptosis and autoimmune diseases.
It offers a unique up–to–date overview on research results on the defective execution of apoptosis and the incomplete clearance of apoptotic cells. The molecular and cellular mechanisms involved are described in detail. As a possible consequence of apoptotic dysfunction, the development of severe autoimmune diseases (e.g., rheumatoid arthritis, systemic lupus erythematosus) is discussed. An outlook on future research topics includes the evaluation of novel therapeutic strategies.
Original languageEnglish
Title of host publicationApoptosis and autoimmunity
Subtitle of host publicationfrom mechanisms to treatments
EditorsM. Hermann, J.R. Kalden
Place of PublicationWeinheim (DE)
PublisherWiley
Pages111-132
Number of pages21
ISBN (Print)3-527-30442-8, 978-3-527-30442-4
Publication statusPublished - 21 Jan 2003

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    Gregory, C. D., & Devitt, A. (2003). Innate immunity and apoptosis: CD14-dependent clearance of apoptotic cells. In M. Hermann, & J. R. Kalden (Eds.), Apoptosis and autoimmunity: from mechanisms to treatments (pp. 111-132). Wiley.