Insights into membrane interactions and their therapeutic potential

Calum Upton; Joseph Healey; Alice J. Rothnie; Alan D. Goddard

doi:10.1016/j.abb.2024.109939

Insights into membrane interactions and their therapeutic potential

Calum Upton
, Joseph Healey
, Alice J. Rothnie
, Alan D. Goddard

Aston University

Research output: Contribution to journal › Article › peer-review

3 Citations (SciVal)

17 Downloads (Pure)

Abstract

Recent research into membrane interactions has uncovered a diverse range of therapeutic opportunities through the bioengineering of human and non-human macromolecules.

Although the majority of this research is focussed on fundamental developments, emerging studies are showcasing promising new technologies to combat conditions such as cancer, Alzheimer's and inflammatory and immune-based disease, utilising the alteration of bacteriophage, adenovirus, bacterial toxins, type 6 secretion systems, annexins, mitochondrial antiviral signalling proteins and bacterial nano-syringes. To advance the field further, each of these opportunities need to be better understood, and the therapeutic models need to be further optimised.

Here, we summarise the knowledge and insights into several membrane interactions and detail their current and potential uses therapeutically.

Original language	English
Article number	109939
Number of pages	18
Journal	Archives of Biochemistry and Biophysics
Volume	755
Early online date	21 Feb 2024
DOIs	https://doi.org/10.1016/j.abb.2024.109939
Publication status	Published - May 2024

Bibliographical note

Funding

CU is part of the MIBTP (Midlands Integrative Biosciences Training Partnership) doctoral training centre funded by the BBSRC (Biotechnology and Biological Sciences Research Council).

Keywords

Membrane interactions
Biotechnology
Bacteriophage T4
Adenovirus
Photorhabdus virulence cassette

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10.1016/j.abb.2024.109939Licence: CC BY 4.0

C Upton et al_Insights into membrane interactions and their therapeutic potential
Copyright © 2024 The Authors. Published by Elsevier Inc. This is an open access article under the CC BY license (https://creativecommons.org/licenses/by/4.0/).
Final published version, 4.09 MBLicence: CC BY 4.0

Cite this

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title = "Insights into membrane interactions and their therapeutic potential",

abstract = "Recent research into membrane interactions has uncovered a diverse range of therapeutic opportunities through the bioengineering of human and non-human macromolecules. Although the majority of this research is focussed on fundamental developments, emerging studies are showcasing promising new technologies to combat conditions such as cancer, Alzheimer's and inflammatory and immune-based disease, utilising the alteration of bacteriophage, adenovirus, bacterial toxins, type 6 secretion systems, annexins, mitochondrial antiviral signalling proteins and bacterial nano-syringes. To advance the field further, each of these opportunities need to be better understood, and the therapeutic models need to be further optimised. Here, we summarise the knowledge and insights into several membrane interactions and detail their current and potential uses therapeutically.",

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Insights into membrane interactions and their therapeutic potential

Abstract

Bibliographical note

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Keywords

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