Predictive models of peptide-Major Histocompatibility Complex (MHC) binding affinity are important components of modern computational immunovaccinology. Here, we describe the development and deployment of a reliable peptide-binding prediction method for a previously poorly-characterized human MHC class I allele, HLA-Cw*0102.
© 2009 Walshe et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
- amino acid motifs
- computational biology
- edetic acid
- HLA-C antigens
- histocompatibility antigens class I
- mononuclear leukocytes
- major histocompatibility complex
- statistical models
- protein binding
- tertiary protein structure