Integrative bioinformatics for functional genorne annotation: trawling for G protein-coupled receptors

Darren R. Flower, Teresa K. Attwood

Research output: Contribution to journalArticlepeer-review


G protein-coupled receptors (GPCR) are amongst the best studied and most functionally diverse types of cell-surface protein. The importance of GPCRs as mediates or cell function and organismal developmental underlies their involvement in key physiological roles and their prominence as targets for pharmacological therapeutics. In this review, we highlight the requirement for integrated protocols which underline the different perspectives offered by different sequence analysis methods. BLAST and FastA offer broad brush strokes. Motif-based search methods add the fine detail. Structural modelling offers another perspective which allows us to elucidate the physicochemical properties that underlie ligand binding. Together, these different views provide a more informative and a more detailed picture of GPCR structure and function. Many GPCRs remain orphan receptors with no identified ligand, yet as computer-driven functional genomics starts to elaborate their functions, a new understanding of their roles in cell and developmental biology will follow.
Original languageEnglish
Pages (from-to)693-701
Number of pages9
JournalSeminars in Cell and Developmental Biology
Issue number6
Early online date17 Nov 2004
Publication statusPublished - Dec 2004


  • gpcr
  • protein superfamily
  • transmembrane protein
  • drug
  • bioinformatics


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