International Union of Pharmacology. LXIX. Status of the calcitonin gene-related peptide subtype 2 receptor

Debbie L. Hay, David R. Poyner, Remi Quirion

Research output: Contribution to journalArticle

Abstract

Historically, calcitonin gene-related peptide (CGRP) receptors have been divided into two classes, CGRP(1) and CGRP(2).After the cloning of calcitonin receptor-like receptor (CLR) and receptor activity-modifying proteins (RAMPs), it became clear that the CGRP(1) receptor was a complex between CLR and RAMP1. It is now apparent that the CGRP(2) receptor phenotype is the result of CGRP acting at receptors for amylin and adrenomedullin. Accordingly, the term "CGRP(2)" receptor should no longer be used, and the "CGRP(1)" receptor should be known as the "CGRP" receptor.
LanguageEnglish
Pages143-145
Number of pages3
JournalPharmacological Reviews
Volume60
Issue number2
DOIs
Publication statusPublished - 9 Jul 2008

Fingerprint

Calcitonin Gene-Related Peptide Receptors
Calcitonin Gene-Related Peptide
Pharmacology
Calcitonin Receptor-Like Protein
Islet Amyloid Polypeptide Receptor
Receptor Activity-Modifying Proteins
Adrenomedullin Receptors
Organism Cloning
Phenotype

Keywords

  • adrenomedullin amyloid receptors
  • calcitonin gene-related peptide

Cite this

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International Union of Pharmacology. LXIX. Status of the calcitonin gene-related peptide subtype 2 receptor. / Hay, Debbie L.; Poyner, David R.; Quirion, Remi.

In: Pharmacological Reviews, Vol. 60, No. 2, 09.07.2008, p. 143-145.

Research output: Contribution to journalArticle

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