TY - JOUR
T1 - International Union of Pharmacology. LXIX. Status of the calcitonin gene-related peptide subtype 2 receptor
AU - Hay, Debbie L.
AU - Poyner, David R.
AU - Quirion, Remi
PY - 2008/7/9
Y1 - 2008/7/9
N2 - Historically, calcitonin gene-related peptide (CGRP) receptors have been divided into two classes, CGRP(1) and CGRP(2).After the cloning of calcitonin receptor-like receptor (CLR) and receptor activity-modifying proteins (RAMPs), it became clear that the CGRP(1) receptor was a complex between CLR and RAMP1. It is now apparent that the CGRP(2) receptor phenotype is the result of CGRP acting at receptors for amylin and adrenomedullin. Accordingly, the term "CGRP(2)" receptor should no longer be used, and the "CGRP(1)" receptor should be known as the "CGRP" receptor.
AB - Historically, calcitonin gene-related peptide (CGRP) receptors have been divided into two classes, CGRP(1) and CGRP(2).After the cloning of calcitonin receptor-like receptor (CLR) and receptor activity-modifying proteins (RAMPs), it became clear that the CGRP(1) receptor was a complex between CLR and RAMP1. It is now apparent that the CGRP(2) receptor phenotype is the result of CGRP acting at receptors for amylin and adrenomedullin. Accordingly, the term "CGRP(2)" receptor should no longer be used, and the "CGRP(1)" receptor should be known as the "CGRP" receptor.
KW - adrenomedullin amyloid receptors
KW - calcitonin gene-related peptide
UR - http://www.scopus.com/inward/record.url?scp=46949111401&partnerID=8YFLogxK
UR - http://pharmrev.aspetjournals.org/content/60/2/143.abstract
U2 - 10.1124/pr.108.00372
DO - 10.1124/pr.108.00372
M3 - Article
SN - 0031-6997
VL - 60
SP - 143
EP - 145
JO - Pharmacological Reviews
JF - Pharmacological Reviews
IS - 2
ER -