TY - JOUR
T1 - Intranasal Delivery of Liposomes to Glioblastoma by Photostimulation of the Lymphatic System
AU - Semyachkina-Glushkovskaya, Oxana
AU - Shirokov, Alexander
AU - Blokhina, Inna
AU - Telnova, Valeria
AU - Vodovozova, Elena
AU - Alekseeva, Anna
AU - Boldyrev, Ivan
AU - Fedosov, Ivan
AU - Dubrovsky, Alexander
AU - Khorovodov, Alexandr
AU - Terskov, Andrey
AU - Evsukova, Arina
AU - Elovenko, Daria
AU - Adushkina, Viktoria
AU - Tzoy, Maria
AU - Agranovich, Ilana
AU - Kurths, Jürgen
AU - Rafailov, Edik
A2 - Gao, Huile
A2 - Lopes, Carla M.
A2 - Catita, José
N1 - Copyright © 2022 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
PY - 2022/12/22
Y1 - 2022/12/22
N2 - The blood–brain barrier (BBB) limits the delivery of majority of cancer drugs and thereby complicates brain tumor treatment. The nasal-brain-lymphatic system is discussed as a pathway for brain drug delivery overcoming the BBB. However, in most cases, this method is not sufficient to achieve a therapeutic effect due to brain drug delivery in a short distance. Therefore, it is necessary to develop technologies to overcome the obstacles facing nose-to-brain delivery of promising pharmaceuticals. In this study, we clearly demonstrate intranasal delivery of liposomes to the mouse brain reaching glioblastoma (GBM). In the experiments with ablation of the meningeal lymphatic network, we report an important role of meningeal pathway for intranasal delivery of liposomes to the brain. Our data revealed that GBM is characterized by a dramatic reduction of intranasal delivery of liposomes to the brain that was significantly improved by near-infrared (1267 nm) photostimulation of the lymphatic vessels in the area of the cribriform plate and the meninges. These results open new perspectives for non-invasive improvement of efficiency of intranasal delivery of cancer drugs to the brain tissues using nanocarriers and near-infrared laser-based therapeutic devices, which are commercially available and widely used in clinical practice.
AB - The blood–brain barrier (BBB) limits the delivery of majority of cancer drugs and thereby complicates brain tumor treatment. The nasal-brain-lymphatic system is discussed as a pathway for brain drug delivery overcoming the BBB. However, in most cases, this method is not sufficient to achieve a therapeutic effect due to brain drug delivery in a short distance. Therefore, it is necessary to develop technologies to overcome the obstacles facing nose-to-brain delivery of promising pharmaceuticals. In this study, we clearly demonstrate intranasal delivery of liposomes to the mouse brain reaching glioblastoma (GBM). In the experiments with ablation of the meningeal lymphatic network, we report an important role of meningeal pathway for intranasal delivery of liposomes to the brain. Our data revealed that GBM is characterized by a dramatic reduction of intranasal delivery of liposomes to the brain that was significantly improved by near-infrared (1267 nm) photostimulation of the lymphatic vessels in the area of the cribriform plate and the meninges. These results open new perspectives for non-invasive improvement of efficiency of intranasal delivery of cancer drugs to the brain tissues using nanocarriers and near-infrared laser-based therapeutic devices, which are commercially available and widely used in clinical practice.
KW - Article
KW - liposomes
KW - nasal-brain lymphatic system
KW - intranasal drug delivery
KW - photostimulation
KW - glioblastoma
UR - https://www.mdpi.com/1999-4923/15/1/36
U2 - 10.3390/pharmaceutics15010036
DO - 10.3390/pharmaceutics15010036
M3 - Article
SN - 1999-4923
VL - 15
JO - Pharmaceutics
JF - Pharmaceutics
IS - 1
ER -