Intranasal Delivery of Liposomes to Glioblastoma by Photostimulation of the Lymphatic System

Oxana Semyachkina-Glushkovskaya; Alexander Shirokov; Inna Blokhina; Valeria Telnova; Elena Vodovozova; Anna Alekseeva; Ivan Boldyrev; Ivan Fedosov; Alexander Dubrovsky; Alexandr Khorovodov; Andrey Terskov; Arina Evsukova; Daria Elovenko; Viktoria Adushkina; Maria Tzoy; Ilana Agranovich; Jürgen Kurths; Edik Rafailov; Huile Gao; Carla M. Lopes; José Catita

doi:10.3390/pharmaceutics15010036

Intranasal Delivery of Liposomes to Glioblastoma by Photostimulation of the Lymphatic System

Oxana Semyachkina-Glushkovskaya^*
, Alexander Shirokov
, Inna Blokhina
, Valeria Telnova
, Elena Vodovozova
, Anna Alekseeva
, Ivan Boldyrev
, Ivan Fedosov
, Alexander Dubrovsky
, Alexandr Khorovodov
, Andrey Terskov
, Arina Evsukova
, Daria Elovenko
, Viktoria Adushkina
, Maria Tzoy
, Ilana Agranovich
, Jürgen Kurths
, Edik Rafailov
, Huile Gao (Editor)
, Carla M. Lopes (Editor)

José Catita (Editor)

^*Corresponding author for this work

Department of Biology, Saratov State University, Astrakhanskaya 82, 410012 Saratov, Russia
Saratov State University , Astrakhanskaya 82 , 410012 Saratov , Russia,Institute of Biochemistry and Physiology of Plants and Microorganisms, Russian Academy of Sciences , Prospekt Entuziastov 13 , 410049 Saratov , Russia
Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences , Miklukho-Maklaya 16/10 , 117997 Moscow , Russia
Department of Complexity Science, Potsdam Institute for Climate Impact Research, Telegrafenberg A31, 14473 Potsdam, Germany

Research output: Contribution to journal › Article › peer-review

35 Citations (Scopus)

14 Downloads (Pure)

Abstract

The blood–brain barrier (BBB) limits the delivery of majority of cancer drugs and thereby complicates brain tumor treatment. The nasal-brain-lymphatic system is discussed as a pathway for brain drug delivery overcoming the BBB. However, in most cases, this method is not sufficient to achieve a therapeutic effect due to brain drug delivery in a short distance. Therefore, it is necessary to develop technologies to overcome the obstacles facing nose-to-brain delivery of promising pharmaceuticals. In this study, we clearly demonstrate intranasal delivery of liposomes to the mouse brain reaching glioblastoma (GBM). In the experiments with ablation of the meningeal lymphatic network, we report an important role of meningeal pathway for intranasal delivery of liposomes to the brain. Our data revealed that GBM is characterized by a dramatic reduction of intranasal delivery of liposomes to the brain that was significantly improved by near-infrared (1267 nm) photostimulation of the lymphatic vessels in the area of the cribriform plate and the meninges. These results open new perspectives for non-invasive improvement of efficiency of intranasal delivery of cancer drugs to the brain tissues using nanocarriers and near-infrared laser-based therapeutic devices, which are commercially available and widely used in clinical practice.

Original language	English
Number of pages	16
Journal	Pharmaceutics
Volume	15
Issue number	1
Early online date	22 Dec 2022
DOIs	https://doi.org/10.3390/pharmaceutics15010036
Publication status	E-pub ahead of print - 22 Dec 2022

Bibliographical note

Copyright © 2022 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

Article
liposomes
nasal-brain lymphatic system
intranasal drug delivery
photostimulation
glioblastoma

Access to Document

10.3390/pharmaceutics15010036Licence: CC BY 4.0

pharmaceutics-15-00036-v3.pdf
Copyright © 2022 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
Final published version, 2.39 MBLicence: CC BY 4.0

Cite this

Semyachkina-Glushkovskaya, O., Shirokov, A., Blokhina, I., Telnova, V., Vodovozova, E., Alekseeva, A., Boldyrev, I., Fedosov, I., Dubrovsky, A., Khorovodov, A., Terskov, A., Evsukova, A., Elovenko, D., Adushkina, V., Tzoy, M., Agranovich, I., Kurths, J., Rafailov, E., Gao, H. (Ed.), ... Catita, J. (Ed.) (2022). Intranasal Delivery of Liposomes to Glioblastoma by Photostimulation of the Lymphatic System. Pharmaceutics, 15(1). Advance online publication. https://doi.org/10.3390/pharmaceutics15010036

@article{1e71229c18ca4ccaa4a53af4ef3ae7d7,

title = "Intranasal Delivery of Liposomes to Glioblastoma by Photostimulation of the Lymphatic System",

abstract = "The blood–brain barrier (BBB) limits the delivery of majority of cancer drugs and thereby complicates brain tumor treatment. The nasal-brain-lymphatic system is discussed as a pathway for brain drug delivery overcoming the BBB. However, in most cases, this method is not sufficient to achieve a therapeutic effect due to brain drug delivery in a short distance. Therefore, it is necessary to develop technologies to overcome the obstacles facing nose-to-brain delivery of promising pharmaceuticals. In this study, we clearly demonstrate intranasal delivery of liposomes to the mouse brain reaching glioblastoma (GBM). In the experiments with ablation of the meningeal lymphatic network, we report an important role of meningeal pathway for intranasal delivery of liposomes to the brain. Our data revealed that GBM is characterized by a dramatic reduction of intranasal delivery of liposomes to the brain that was significantly improved by near-infrared (1267 nm) photostimulation of the lymphatic vessels in the area of the cribriform plate and the meninges. These results open new perspectives for non-invasive improvement of efficiency of intranasal delivery of cancer drugs to the brain tissues using nanocarriers and near-infrared laser-based therapeutic devices, which are commercially available and widely used in clinical practice.",

keywords = "Article, liposomes, nasal-brain lymphatic system, intranasal drug delivery, photostimulation, glioblastoma",

author = "Oxana Semyachkina-Glushkovskaya and Alexander Shirokov and Inna Blokhina and Valeria Telnova and Elena Vodovozova and Anna Alekseeva and Ivan Boldyrev and Ivan Fedosov and Alexander Dubrovsky and Alexandr Khorovodov and Andrey Terskov and Arina Evsukova and Daria Elovenko and Viktoria Adushkina and Maria Tzoy and Ilana Agranovich and J{\"u}rgen Kurths and Edik Rafailov and Huile Gao and Lopes, \{Carla M.\} and Jos{\'e} Catita",

note = "Copyright {\textcopyright} 2022 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).",

year = "2022",

month = dec,

day = "22",

doi = "10.3390/pharmaceutics15010036",

language = "English",

volume = "15",

journal = "Pharmaceutics",

issn = "1999-4923",

publisher = "MDPI AG",

number = "1",

}

Semyachkina-Glushkovskaya, O, Shirokov, A, Blokhina, I, Telnova, V, Vodovozova, E, Alekseeva, A, Boldyrev, I, Fedosov, I, Dubrovsky, A, Khorovodov, A, Terskov, A, Evsukova, A, Elovenko, D, Adushkina, V, Tzoy, M, Agranovich, I, Kurths, J, Rafailov, E, Gao, H (ed.), Lopes, CM (ed.) & Catita, J (ed.) 2022, 'Intranasal Delivery of Liposomes to Glioblastoma by Photostimulation of the Lymphatic System', Pharmaceutics, vol. 15, no. 1. https://doi.org/10.3390/pharmaceutics15010036

TY - JOUR

T1 - Intranasal Delivery of Liposomes to Glioblastoma by Photostimulation of the Lymphatic System

AU - Semyachkina-Glushkovskaya, Oxana

AU - Shirokov, Alexander

AU - Blokhina, Inna

AU - Telnova, Valeria

AU - Vodovozova, Elena

AU - Alekseeva, Anna

AU - Boldyrev, Ivan

AU - Fedosov, Ivan

AU - Dubrovsky, Alexander

AU - Khorovodov, Alexandr

AU - Terskov, Andrey

AU - Evsukova, Arina

AU - Elovenko, Daria

AU - Adushkina, Viktoria

AU - Tzoy, Maria

AU - Agranovich, Ilana

AU - Kurths, Jürgen

AU - Rafailov, Edik

A2 - Gao, Huile

A2 - Lopes, Carla M.

A2 - Catita, José

N1 - Copyright © 2022 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

PY - 2022/12/22

Y1 - 2022/12/22

N2 - The blood–brain barrier (BBB) limits the delivery of majority of cancer drugs and thereby complicates brain tumor treatment. The nasal-brain-lymphatic system is discussed as a pathway for brain drug delivery overcoming the BBB. However, in most cases, this method is not sufficient to achieve a therapeutic effect due to brain drug delivery in a short distance. Therefore, it is necessary to develop technologies to overcome the obstacles facing nose-to-brain delivery of promising pharmaceuticals. In this study, we clearly demonstrate intranasal delivery of liposomes to the mouse brain reaching glioblastoma (GBM). In the experiments with ablation of the meningeal lymphatic network, we report an important role of meningeal pathway for intranasal delivery of liposomes to the brain. Our data revealed that GBM is characterized by a dramatic reduction of intranasal delivery of liposomes to the brain that was significantly improved by near-infrared (1267 nm) photostimulation of the lymphatic vessels in the area of the cribriform plate and the meninges. These results open new perspectives for non-invasive improvement of efficiency of intranasal delivery of cancer drugs to the brain tissues using nanocarriers and near-infrared laser-based therapeutic devices, which are commercially available and widely used in clinical practice.

AB - The blood–brain barrier (BBB) limits the delivery of majority of cancer drugs and thereby complicates brain tumor treatment. The nasal-brain-lymphatic system is discussed as a pathway for brain drug delivery overcoming the BBB. However, in most cases, this method is not sufficient to achieve a therapeutic effect due to brain drug delivery in a short distance. Therefore, it is necessary to develop technologies to overcome the obstacles facing nose-to-brain delivery of promising pharmaceuticals. In this study, we clearly demonstrate intranasal delivery of liposomes to the mouse brain reaching glioblastoma (GBM). In the experiments with ablation of the meningeal lymphatic network, we report an important role of meningeal pathway for intranasal delivery of liposomes to the brain. Our data revealed that GBM is characterized by a dramatic reduction of intranasal delivery of liposomes to the brain that was significantly improved by near-infrared (1267 nm) photostimulation of the lymphatic vessels in the area of the cribriform plate and the meninges. These results open new perspectives for non-invasive improvement of efficiency of intranasal delivery of cancer drugs to the brain tissues using nanocarriers and near-infrared laser-based therapeutic devices, which are commercially available and widely used in clinical practice.

KW - Article

KW - liposomes

KW - nasal-brain lymphatic system

KW - intranasal drug delivery

KW - photostimulation

KW - glioblastoma

UR - https://www.mdpi.com/1999-4923/15/1/36

U2 - 10.3390/pharmaceutics15010036

DO - 10.3390/pharmaceutics15010036

M3 - Article

SN - 1999-4923

VL - 15

JO - Pharmaceutics

JF - Pharmaceutics

IS - 1

ER -

Intranasal Delivery of Liposomes to Glioblastoma by Photostimulation of the Lymphatic System

Abstract

Bibliographical note

UN SDGs

Keywords

Access to Document

Other files and links

Fingerprint

Cite this