Investigating the molecular structures of solid dispersions by the simulated annealing method

Defang Ouyang

Research output: Contribution to journalArticle

Abstract

Knowledge of the molecular structures of solid dispersions is vital, yet, despite thousands of reports in this area, it remains unclear. The aim of this research is to investigate the molecular structure of solid dispersions with hot melt preparation method by the simulated annealing method. Simulation results showed linear polymer chains form the random coils under heat and the drug molecules stick on the surface of polymer coils, while drug molecules are dispersed molecularly but irregularly within the amorphous low molecular weight carriers. This research presents more reasonable molecular images of solid dispersions than the existed theory.
Original languageEnglish
Pages (from-to)177-184
Number of pages8
JournalChemical Physics Letters
Volume554
DOIs
Publication statusPublished - 3 Dec 2012

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