Investigating Voice as a Biomarker for Leucine-Rich Repeat Kinase 2-Associated Parkinson's Disease

Siddharth Arora, Naomi P. Visanji, Tiago A. Mestre, Athanasios Tsanas, Amaal AlDakheel, Barbara S. Connolly, Carmen Gasca-Salas, Drew S. Kern, Jennifer Jain, Elizabeth J. Slow, Achinoam Faust-Socher, Anthony E. Lang, Max A. Little, Connie Marras

Research output: Contribution to journalArticlepeer-review


We investigate the potential association between leucine-rich repeat kinase 2 (LRRK2) mutations and voice. Sustained phonations ('aaah' sounds) were recorded from 7 individuals with LRRK2-associated Parkinson's disease (PD), 17 participants with idiopathic PD (iPD), 20 non-manifesting LRRK2-mutation carriers, 25 related non-carriers, and 26 controls. In distinguishing LRRK2-associated PD and iPD, the mean sensitivity was 95.4% (SD 17.8%) and mean specificity was 89.6% (SD 26.5%). Voice features for non-manifesting carriers, related non-carriers, and controls were much less discriminatory. Vocal deficits in LRRK2-associated PD may be different than those in iPD. These preliminary results warrant longitudinal analyses and replication in larger cohorts.

Original languageEnglish
Pages (from-to)503-510
Number of pages8
JournalJournal of Parkinson's Disease
Issue number4
Publication statusPublished - 17 Oct 2018

Bibliographical note

©2018 IOS Press.


  • biomarker
  • LRRK2 mutation
  • Parkinson’s disease
  • voice


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