Propionibacterium acnes: infection beyond the skin

Alexandra Perry, Peter Lambert*

*Corresponding author for this work

Research output: Contribution to journalReview article

Abstract

Propionibacterium acnes is a Gram-positive bacterium that forms part of the normal flora of the skin, oral cavity, large intestine, the conjunctiva and the external ear canal. Although primarily recognized for its role in acne, P. acnes is an opportunistic pathogen, causing a range of postoperative and device-related infections. These include infections of the bones and joints, mouth, eye and brain. Device-related infections include those of joint prostheses, shunts and prosthetic heart valves. P. acnes may play a role in other conditions, including inflammation of the prostate leading to cancer, SAPHO (synovitis, acne, pustulosis, hyperostosis, osteitis) syndrome, sarcoidosis and sciatica. If an active role in these conditions is established there are major implications for diagnosis, treatment and protection. Genome sequencing of the organism has provided an insight into the pathogenic potential and virulence of P. acnes.

Original languageEnglish
Pages (from-to)1149-1156
Number of pages8
JournalExpert Review of Anti-Infective Therapy
Volume9
Issue number12
DOIs
Publication statusPublished - 2011

Fingerprint

Propionibacterium acnes
Skin
Acne Vulgaris
Infection
Mouth
Joint Prosthesis
Hyperostosis
Sciatica
Osteitis
Equipment and Supplies
Ear Canal
Synovitis
Conjunctiva
Large Intestine
Heart Valves
Gram-Positive Bacteria
Sarcoidosis
Virulence
Prostate
Joints

Keywords

  • device related
  • infection
  • inflammation
  • opportunistic pathogen
  • propionibacterium acnes
  • skin commensal

Cite this

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title = "Propionibacterium acnes: infection beyond the skin",
abstract = "Propionibacterium acnes is a Gram-positive bacterium that forms part of the normal flora of the skin, oral cavity, large intestine, the conjunctiva and the external ear canal. Although primarily recognized for its role in acne, P. acnes is an opportunistic pathogen, causing a range of postoperative and device-related infections. These include infections of the bones and joints, mouth, eye and brain. Device-related infections include those of joint prostheses, shunts and prosthetic heart valves. P. acnes may play a role in other conditions, including inflammation of the prostate leading to cancer, SAPHO (synovitis, acne, pustulosis, hyperostosis, osteitis) syndrome, sarcoidosis and sciatica. If an active role in these conditions is established there are major implications for diagnosis, treatment and protection. Genome sequencing of the organism has provided an insight into the pathogenic potential and virulence of P. acnes.",
keywords = "device related, infection, inflammation, opportunistic pathogen, propionibacterium acnes, skin commensal",
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}

Propionibacterium acnes : infection beyond the skin. / Perry, Alexandra; Lambert, Peter.

In: Expert Review of Anti-Infective Therapy, Vol. 9, No. 12, 2011, p. 1149-1156.

Research output: Contribution to journalReview article

TY - JOUR

T1 - Propionibacterium acnes

T2 - infection beyond the skin

AU - Perry, Alexandra

AU - Lambert, Peter

PY - 2011

Y1 - 2011

N2 - Propionibacterium acnes is a Gram-positive bacterium that forms part of the normal flora of the skin, oral cavity, large intestine, the conjunctiva and the external ear canal. Although primarily recognized for its role in acne, P. acnes is an opportunistic pathogen, causing a range of postoperative and device-related infections. These include infections of the bones and joints, mouth, eye and brain. Device-related infections include those of joint prostheses, shunts and prosthetic heart valves. P. acnes may play a role in other conditions, including inflammation of the prostate leading to cancer, SAPHO (synovitis, acne, pustulosis, hyperostosis, osteitis) syndrome, sarcoidosis and sciatica. If an active role in these conditions is established there are major implications for diagnosis, treatment and protection. Genome sequencing of the organism has provided an insight into the pathogenic potential and virulence of P. acnes.

AB - Propionibacterium acnes is a Gram-positive bacterium that forms part of the normal flora of the skin, oral cavity, large intestine, the conjunctiva and the external ear canal. Although primarily recognized for its role in acne, P. acnes is an opportunistic pathogen, causing a range of postoperative and device-related infections. These include infections of the bones and joints, mouth, eye and brain. Device-related infections include those of joint prostheses, shunts and prosthetic heart valves. P. acnes may play a role in other conditions, including inflammation of the prostate leading to cancer, SAPHO (synovitis, acne, pustulosis, hyperostosis, osteitis) syndrome, sarcoidosis and sciatica. If an active role in these conditions is established there are major implications for diagnosis, treatment and protection. Genome sequencing of the organism has provided an insight into the pathogenic potential and virulence of P. acnes.

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KW - infection

KW - inflammation

KW - opportunistic pathogen

KW - propionibacterium acnes

KW - skin commensal

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