TY - JOUR
T1 - Propionibacterium acnes
T2 - infection beyond the skin
AU - Perry, Alexandra
AU - Lambert, Peter
PY - 2011
Y1 - 2011
N2 - Propionibacterium acnes is a Gram-positive bacterium that forms part of the normal flora of the skin, oral cavity, large intestine, the conjunctiva and the external ear canal. Although primarily recognized for its role in acne, P. acnes is an opportunistic pathogen, causing a range of postoperative and device-related infections. These include infections of the bones and joints, mouth, eye and brain. Device-related infections include those of joint prostheses, shunts and prosthetic heart valves. P. acnes may play a role in other conditions, including inflammation of the prostate leading to cancer, SAPHO (synovitis, acne, pustulosis, hyperostosis, osteitis) syndrome, sarcoidosis and sciatica. If an active role in these conditions is established there are major implications for diagnosis, treatment and protection. Genome sequencing of the organism has provided an insight into the pathogenic potential and virulence of P. acnes.
AB - Propionibacterium acnes is a Gram-positive bacterium that forms part of the normal flora of the skin, oral cavity, large intestine, the conjunctiva and the external ear canal. Although primarily recognized for its role in acne, P. acnes is an opportunistic pathogen, causing a range of postoperative and device-related infections. These include infections of the bones and joints, mouth, eye and brain. Device-related infections include those of joint prostheses, shunts and prosthetic heart valves. P. acnes may play a role in other conditions, including inflammation of the prostate leading to cancer, SAPHO (synovitis, acne, pustulosis, hyperostosis, osteitis) syndrome, sarcoidosis and sciatica. If an active role in these conditions is established there are major implications for diagnosis, treatment and protection. Genome sequencing of the organism has provided an insight into the pathogenic potential and virulence of P. acnes.
KW - device related
KW - infection
KW - inflammation
KW - opportunistic pathogen
KW - propionibacterium acnes
KW - skin commensal
UR - http://www.scopus.com/inward/record.url?scp=82455186473&partnerID=8YFLogxK
UR - http://www.tandfonline.com/10.1586/eri.11.137
U2 - 10.1586/eri.11.137
DO - 10.1586/eri.11.137
M3 - Review article
C2 - 22114965
AN - SCOPUS:82455186473
SN - 1478-7210
VL - 9
SP - 1149
EP - 1156
JO - Expert Review of Anti-Infective Therapy
JF - Expert Review of Anti-Infective Therapy
IS - 12
ER -