Isomer resolution by micelle-assisted diffusion-ordered spectroscopy

Robert Evans, Stephan Haiber, Mathias Nilsson, Gareth A. Morris

Research output: Contribution to journalArticle

Abstract

Diffusion-ordered NMR spectroscopy ("DOSY") is a useful tool for the identification of mixture components. In its basic form it relies on simple differences in hydrodynamic radius to distinguish between different species. This can be very effective where species have significantly different molecular sizes, but generally fails for isomeric species. The use of surfactant co-solutes can allow isomeric species to be distinguished by virtue of their different degrees of interaction with micelles or reversed micelles. The use of micelle-assisted DOSY to resolve the NMR spectra of isomers is illustrated for the case of the three dihydroxybenzenes (catechol, resorcinol, and hydroquinone) in aqueous solution containing sodium dodecyl sulfate micelles, and in chloroform solution containing AOT reversed micelles.
Original languageEnglish
Pages (from-to)4548-4550
Number of pages3
JournalAnalytical Chemistry
Volume81
Issue number11
DOIs
Publication statusPublished - 1 Jun 2009

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