Laminar distribution of β-amyloid deposits in dementia with Lewy bodies and in Alzheimer's disease

Richard A. Armstrong*

*Corresponding author for this work

Research output: Contribution to journalArticle

Abstract

This study tested whether the laminar distribution of the β-amyloid (Aβ) deposits in dementia with Lewy bodies (DLB) cases with significant Alzheimer's disease (AD) pathology (DLB/AD) was similar to "pure" AD. In DLB/AD, the maximum density of the diffuse and primitive deposits occurred either in the upper laminae or a bimodal distribution was present with density peaks in the upper and lower laminae. A bimodal distribution of the classic Aβ deposits was also observed. Compared with AD, DLB/AD cases had fewer primitive deposits relative to the diffuse and classic deposits; the primitive deposits exhibited a bimodal distribution more frequently, and the diffuse deposits occurred more often in the upper laminae. These results suggest that Aβ pathology in DLB/AD may not simply represent the presence of associated AD. © 2006 Sage Publications.

Original languageEnglish
Pages (from-to)175-181
Number of pages7
JournalAmerican Journal of Alzheimer's Disease and other Dementias
Volume21
Issue number3
DOIs
Publication statusPublished - Mar 2006

Keywords

  • β-amyloid (aβ) deposits
  • Alzheimer's disease (AD)
  • cortico-cortical pathways
  • dementia with Lewy bodies (DLB)
  • laminar distribution

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