Laminar distribution of ballooned neurons and tau positive neurons with inclusions in patients with corticobasal degeneration

Richard A. Armstrong

Research output: Contribution to journalArticle

Abstract

The laminar distribution of ballooned neurons (BN) and tau positive neurons with inclusions (tau+ neurons) was studied in the frontal and temporal cortex in twelve patients with corticobasal degeneration (CBD). In the majority of brain areas, the density of BN and tau+ neurons was maximal in the lower and upper cortical laminae respectively. The densities of tau+ neurons in the upper and lower cortex were positively correlated. In the majority of brain areas, however, no correlations were observed between the densities of BN and tau+ neurons. The laminar distribution of the BN may reflect the degeneration of the feedback cortico-cortical and/or the efferent cortical pathways. By contrast, the distribution of the tau+ neurons may reflect the degeneration of the feed-forward cortico-cortical pathways. In addition, BN and tau+ neurons may arise as a result of distinct pathological processes.
Original languageEnglish
Pages (from-to)85-93
Number of pages9
JournalNeuroscience Research Communications
Volume27
Issue number2
DOIs
Publication statusPublished - 13 Nov 2000

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Neurons
Efferent Pathways
Brain
Frontal Lobe
Pathologic Processes
Temporal Lobe

Keywords

  • corticobasal degeneration
  • ballooned neurons
  • tau positive neurons
  • laminar distribution
  • cortico-cortical pathways

Cite this

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abstract = "The laminar distribution of ballooned neurons (BN) and tau positive neurons with inclusions (tau+ neurons) was studied in the frontal and temporal cortex in twelve patients with corticobasal degeneration (CBD). In the majority of brain areas, the density of BN and tau+ neurons was maximal in the lower and upper cortical laminae respectively. The densities of tau+ neurons in the upper and lower cortex were positively correlated. In the majority of brain areas, however, no correlations were observed between the densities of BN and tau+ neurons. The laminar distribution of the BN may reflect the degeneration of the feedback cortico-cortical and/or the efferent cortical pathways. By contrast, the distribution of the tau+ neurons may reflect the degeneration of the feed-forward cortico-cortical pathways. In addition, BN and tau+ neurons may arise as a result of distinct pathological processes.",
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Laminar distribution of ballooned neurons and tau positive neurons with inclusions in patients with corticobasal degeneration. / Armstrong, Richard A.

In: Neuroscience Research Communications, Vol. 27, No. 2, 13.11.2000, p. 85-93.

Research output: Contribution to journalArticle

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