Laminar distribution of cortical Lewy bodies and neurofibrillary tangles in dementia with Lewy bodies

Richard A. Armstrong, N.J Cairns, P.L. Lantos

Research output: Contribution to journalArticlepeer-review

Abstract

The laminar distribution of Lewy bodies (LB) and neurofibrillary tangles (NFT) was studied in twelve cases of dementia with Lewy bodies (DLB). LB density was maximal in the lower cortex in 59% of cortical areas, in the upper cortex in 31% of areas while densities were similar in the upper and lower cortex in 9% of areas. The distribution of LB was either unimodal with a lower cortical peak, or bimodal with density peaks in the upper and lower cortex. The density of NFT was maximal in the upper cortex in all tissues. The distributions of LB and NFT were similar in temporal and frontal cortex and in cases with and without Alzheimer’s disease (AD). The vertical densities of LB and NFT were not significantly correlated. LB formation may affect the feedback cortico-cortical pathway and the efferent cortical projections whereas NFT formation may affect the feedforward cortico-cortical pathway.
Original languageEnglish
Pages (from-to)145-152
Number of pages8
JournalNeuroscience Research Communications
Volume21
Issue number2
Publication statusPublished - Sep 1997

Keywords

  • dementia with Lewy bodies
  • Lewy body
  • neurofibrillary tangles
  • laminar distribution
  • Alzheimer’s disease

Fingerprint

Dive into the research topics of 'Laminar distribution of cortical Lewy bodies and neurofibrillary tangles in dementia with Lewy bodies'. Together they form a unique fingerprint.

Cite this