Laminar distribution of the pathological changes in sporadic and variant Creutzfeldt-Jakob disease

Richard A. Armstrong

Research output: Contribution to journalArticle

Abstract

The laminar distributions of the pathological changes in the cerebral cortex were compared in the prion diseases sporadic Creutzfeldt-Jakob disease (sCJD) and variant CJD (vCJD). First, in some cortical regions the vacuolation (‘spongiform change’) was more generally distributed across the cortex in sCJD. Second, there was greater neuronal loss in the upper cortex in vCJD and in the lower cortex in sCJD. Third, the ‘diffuse’ and ‘florid’ prion protein (PrPsc) deposits were more frequently distributed in the upper cortex in vCJD and the ‘synaptic’ deposits in the lower cortex in sCJD. Fourth, there was a significant gliosis mainly affecting the lower cortex of both disorders. The data suggest that the pattern of cortical degeneration is different in sCJD and vCJD which may reflect differences in aetiology and the subsequent spread of prion pathology in the brain.
Original languageEnglish
Pages (from-to)1-7
Number of pages7
JournalPathology Research International
Volume2011
DOIs
Publication statusPublished - 2011

Fingerprint

Creutzfeldt-Jakob Syndrome
Prion Diseases
Gliosis
Prions
Cerebral Cortex
Sporadic Creutzfeldt-Jakob Disease
Pathology
Brain

Bibliographical note

Copyright © 2011 R. A. Armstrong. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Keywords

  • laminar distributions
  • pathological changes
  • cerebral cortex
  • prion diseases sporadic
  • Creutzfeldt-Jakob disease
  • sCJD
  • variant CJD
  • vCJD
  • vacuolation
  • neuronal loss
  • prion protein
  • PrPsc
  • deposits
  • gliosis
  • cortical degeneration
  • aetiology
  • prion pathology
  • brain

Cite this

@article{324c5611588249f2a33091541228082b,
title = "Laminar distribution of the pathological changes in sporadic and variant Creutzfeldt-Jakob disease",
abstract = "The laminar distributions of the pathological changes in the cerebral cortex were compared in the prion diseases sporadic Creutzfeldt-Jakob disease (sCJD) and variant CJD (vCJD). First, in some cortical regions the vacuolation (‘spongiform change’) was more generally distributed across the cortex in sCJD. Second, there was greater neuronal loss in the upper cortex in vCJD and in the lower cortex in sCJD. Third, the ‘diffuse’ and ‘florid’ prion protein (PrPsc) deposits were more frequently distributed in the upper cortex in vCJD and the ‘synaptic’ deposits in the lower cortex in sCJD. Fourth, there was a significant gliosis mainly affecting the lower cortex of both disorders. The data suggest that the pattern of cortical degeneration is different in sCJD and vCJD which may reflect differences in aetiology and the subsequent spread of prion pathology in the brain.",
keywords = "laminar distributions, pathological changes, cerebral cortex, prion diseases sporadic, Creutzfeldt-Jakob disease, sCJD, variant CJD, vCJD, vacuolation, neuronal loss, prion protein, PrPsc, deposits, gliosis, cortical degeneration, aetiology, prion pathology, brain",
author = "Armstrong, {Richard A.}",
note = "Copyright {\circledC} 2011 R. A. Armstrong. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.",
year = "2011",
doi = "10.4061/2011/236346",
language = "English",
volume = "2011",
pages = "1--7",
journal = "Pathology Research International",
issn = "2042-003X",
publisher = "Hindawi Publishing Corporation",

}

Laminar distribution of the pathological changes in sporadic and variant Creutzfeldt-Jakob disease. / Armstrong, Richard A.

In: Pathology Research International, Vol. 2011, 2011, p. 1-7.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Laminar distribution of the pathological changes in sporadic and variant Creutzfeldt-Jakob disease

AU - Armstrong, Richard A.

N1 - Copyright © 2011 R. A. Armstrong. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

PY - 2011

Y1 - 2011

N2 - The laminar distributions of the pathological changes in the cerebral cortex were compared in the prion diseases sporadic Creutzfeldt-Jakob disease (sCJD) and variant CJD (vCJD). First, in some cortical regions the vacuolation (‘spongiform change’) was more generally distributed across the cortex in sCJD. Second, there was greater neuronal loss in the upper cortex in vCJD and in the lower cortex in sCJD. Third, the ‘diffuse’ and ‘florid’ prion protein (PrPsc) deposits were more frequently distributed in the upper cortex in vCJD and the ‘synaptic’ deposits in the lower cortex in sCJD. Fourth, there was a significant gliosis mainly affecting the lower cortex of both disorders. The data suggest that the pattern of cortical degeneration is different in sCJD and vCJD which may reflect differences in aetiology and the subsequent spread of prion pathology in the brain.

AB - The laminar distributions of the pathological changes in the cerebral cortex were compared in the prion diseases sporadic Creutzfeldt-Jakob disease (sCJD) and variant CJD (vCJD). First, in some cortical regions the vacuolation (‘spongiform change’) was more generally distributed across the cortex in sCJD. Second, there was greater neuronal loss in the upper cortex in vCJD and in the lower cortex in sCJD. Third, the ‘diffuse’ and ‘florid’ prion protein (PrPsc) deposits were more frequently distributed in the upper cortex in vCJD and the ‘synaptic’ deposits in the lower cortex in sCJD. Fourth, there was a significant gliosis mainly affecting the lower cortex of both disorders. The data suggest that the pattern of cortical degeneration is different in sCJD and vCJD which may reflect differences in aetiology and the subsequent spread of prion pathology in the brain.

KW - laminar distributions

KW - pathological changes

KW - cerebral cortex

KW - prion diseases sporadic

KW - Creutzfeldt-Jakob disease

KW - sCJD

KW - variant CJD

KW - vCJD

KW - vacuolation

KW - neuronal loss

KW - prion protein

KW - PrPsc

KW - deposits

KW - gliosis

KW - cortical degeneration

KW - aetiology

KW - prion pathology

KW - brain

UR - https://www.hindawi.com/journals/pri/2011/236346/

U2 - 10.4061/2011/236346

DO - 10.4061/2011/236346

M3 - Article

VL - 2011

SP - 1

EP - 7

JO - Pathology Research International

JF - Pathology Research International

SN - 2042-003X

ER -