Lamotrigine-induced seizure aggravation and negative myoclonus in indiopathic rolandic epilepsy

Caterina Cerminara; Maria Lucia Montanaro; Paolo Curatolo; Stefano Seri

doi:10.1212/01.WNL.0000130195.62670.A6

Lamotrigine-induced seizure aggravation and negative myoclonus in indiopathic rolandic epilepsy

Caterina Cerminara, Maria Lucia Montanaro, Paolo Curatolo, Stefano Seri^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

Abstract

The authors describe a paradoxical reaction to lamotrigine (LTG) treatment in a patient with idiopathic rolandic epilepsy characterized by seizure deterioration, the appearance of new seizure type, and transient cognitive impairment. This phenomenon was present at a low dose after a slow titration and promptly reverted on LTG discontinuation. This rare event may have similarities with carbamazepine-induced seizure worsening caused by the Na⁺⁺ channel inhibitory effect of the two antiepileptic drugs.

Original language	English
Pages (from-to)	373-375
Number of pages	3
Journal	Neurology
Volume	63
Issue number	2
DOIs	https://doi.org/10.1212/01.WNL.0000130195.62670.A6
Publication status	Published - 27 Jul 2004

Keywords

toxicology
epilepsy
antiepileptic drugs
myoclonus

Access to Document

10.1212/01.WNL.0000130195.62670.A6

Cite this

@article{3c7824615d474e8e81f0455ed3fa1b87,

title = "Lamotrigine-induced seizure aggravation and negative myoclonus in indiopathic rolandic epilepsy",

abstract = "The authors describe a paradoxical reaction to lamotrigine (LTG) treatment in a patient with idiopathic rolandic epilepsy characterized by seizure deterioration, the appearance of new seizure type, and transient cognitive impairment. This phenomenon was present at a low dose after a slow titration and promptly reverted on LTG discontinuation. This rare event may have similarities with carbamazepine-induced seizure worsening caused by the Na++ channel inhibitory effect of the two antiepileptic drugs.",

keywords = "toxicology, epilepsy, antiepileptic drugs, myoclonus",

author = "Caterina Cerminara and Montanaro, {Maria Lucia} and Paolo Curatolo and Stefano Seri",

year = "2004",

month = jul,

day = "27",

doi = "10.1212/01.WNL.0000130195.62670.A6",

language = "English",

volume = "63",

pages = "373--375",

journal = "Neurology ",

issn = "0028-3878",

number = "2",

}

TY - JOUR

T1 - Lamotrigine-induced seizure aggravation and negative myoclonus in indiopathic rolandic epilepsy

AU - Cerminara, Caterina

AU - Montanaro, Maria Lucia

AU - Curatolo, Paolo

AU - Seri, Stefano

PY - 2004/7/27

Y1 - 2004/7/27

N2 - The authors describe a paradoxical reaction to lamotrigine (LTG) treatment in a patient with idiopathic rolandic epilepsy characterized by seizure deterioration, the appearance of new seizure type, and transient cognitive impairment. This phenomenon was present at a low dose after a slow titration and promptly reverted on LTG discontinuation. This rare event may have similarities with carbamazepine-induced seizure worsening caused by the Na++ channel inhibitory effect of the two antiepileptic drugs.

AB - The authors describe a paradoxical reaction to lamotrigine (LTG) treatment in a patient with idiopathic rolandic epilepsy characterized by seizure deterioration, the appearance of new seizure type, and transient cognitive impairment. This phenomenon was present at a low dose after a slow titration and promptly reverted on LTG discontinuation. This rare event may have similarities with carbamazepine-induced seizure worsening caused by the Na++ channel inhibitory effect of the two antiepileptic drugs.

KW - toxicology

KW - epilepsy

KW - antiepileptic drugs

KW - myoclonus

UR - http://www.scopus.com/inward/record.url?scp=3242758971&partnerID=8YFLogxK

UR - https://n.neurology.org/content/63/2/373

U2 - 10.1212/01.WNL.0000130195.62670.A6

DO - 10.1212/01.WNL.0000130195.62670.A6

M3 - Article

C2 - 15277643

AN - SCOPUS:3242758971

SN - 0028-3878

VL - 63

SP - 373

EP - 375

JO - Neurology

JF - Neurology

IS - 2

ER -

Lamotrigine-induced seizure aggravation and negative myoclonus in indiopathic rolandic epilepsy

Abstract

Keywords

Access to Document

Other files and links

Fingerprint

Cite this