Language and reading impairments are associated with increased prevalence of non‐right‐handedness

Filippo Abbondanza; Philip S. Dale; Carol A. Wang; Marianna E. Hayiou‐Thomas; Umar Toseeb; Tanner S. Koomar; Karen G. Wigg; Yu Feng; Kaitlyn M. Price; Elizabeth N. Kerr; Sharon L. Guger; Maureen W. Lovett; Lisa J. Strug; Elsje van Bergen; Conor V. Dolan; J. Bruce Tomblin; Kristina Moll; Gerd Schulte‐Körne; Nina Neuhoff; Andreas Warnke; Simon E. Fisher; Cathy L. Barr; Jacob J. Michaelson; Dorret I. Boomsma; Margaret J. Snowling; Charles Hulme; Andrew J. O. Whitehouse; Craig E. Pennell; Dianne F. Newbury; John Stein; Joel B. Talcott; Dorothy V. M. Bishop; Silvia Paracchini

doi:10.1111/cdev.13914

Language and reading impairments are associated with increased prevalence of non‐right‐handedness

Filippo Abbondanza
, Philip S. Dale
, Carol A. Wang
, Marianna E. Hayiou‐Thomas
, Umar Toseeb
, Tanner S. Koomar
, Karen G. Wigg
, Yu Feng
, Kaitlyn M. Price
, Elizabeth N. Kerr
, Sharon L. Guger
, Maureen W. Lovett
, Lisa J. Strug
, Elsje van Bergen
, Conor V. Dolan
, J. Bruce Tomblin
, Kristina Moll
, Gerd Schulte‐Körne
, Nina Neuhoff
, Andreas Warnke

Simon E. Fisher, Cathy L. Barr, Jacob J. Michaelson, Dorret I. Boomsma, Margaret J. Snowling, Charles Hulme, Andrew J. O. Whitehouse, Craig E. Pennell, Dianne F. Newbury, John Stein, Joel B. Talcott, Dorothy V. M. Bishop, Silvia Paracchini^*

^*Corresponding author for this work

School of Medicine, University of St Andrews, St Andrews, UK.
Department of Speech and Hearing Sciences University of New Mexico Albuquerque New Mexico USA
School of Medicine and Public Health University of Newcastle Callaghan New South Wales Australia
Department of Psychology, University of York, York, UK.
Department of Education University of York York UK
Department of Psychiatry The University of Iowa Iowa City Iowa USA
Division of Experimental and Translational Neuroscience, Krembil Research Institute University Health Network Toronto Ontario Canada
Department of Physiology University of Toronto Toronto Ontario Canada
Department of Psychology Hospital for Sick Children Toronto Ontario Canada
Department of Paediatrics University of Toronto Toronto Ontario Canada
Dalla Lana School of Public Health University of Toronto Toronto Ontario Canada
Department of Biological Psychology Vrije Universiteit Amsterdam Amsterdam The Netherlands
Department of Child and Adolescent Psychiatry, Psychotherapy and Psychosomatics Ludwig‐Maximilians‐University Hospital Munich Munchen Germany
Julius‐Maximilians‐University Würzburg Würzburg Germany
Radboud University Nijmegen, Donders Institute for Brain, Cognition and Behaviour, Centre for Cognitive Neuroimaging, The Netherlands.
Department of Experimental Psychology, Anna Watts Building, University of Oxford, Oxford; Oxford University Hospitals NHS Foundation Trust, Oxford, UK; Department of Psychiatry, Warneford Hospital, Warneford Ln, Headington, Oxford
University of Oxford
Telethon Kids Institute, The University of Western Australia, Perth, Australia
Department of Biological and Medical Sciences, Oxford Brookes University
Department of Physiology, Anatomy and Genetics, University of Oxford, Oxford, UK. [email protected].; Oxford Parkinson's Disease Centre, University of Oxford, Oxford, UK. [email protected].

Research output: Contribution to journal › Article › peer-review

16 Citations (Scopus)

25 Downloads (Pure)

Abstract

Handedness has been studied for association with language‐related disorders because of its link with language hemispheric dominance. No clear pattern has emerged, possibly because of small samples, publication bias, and heterogeneous criteria across studies. Non‐right‐handedness (NRH) frequency was assessed in N = 2503 cases with reading and/or language impairment and N = 4316 sex‐matched controls identified from 10 distinct cohorts (age range 6–19 years old; European ethnicity) using a priori set criteria. A meta‐analysis (Ncases = 1994) showed elevated NRH % in individuals with language/reading impairment compared with controls (OR = 1.21, CI = 1.06–1.39, p = .01). The association between reading/language impairments and NRH could result from shared pathways underlying brain lateralization, handedness, and cognitive functions.

Original language	English
Pages (from-to)	970-984
Number of pages	15
Journal	Child Development
Volume	94
Issue number	4
Early online date	13 Feb 2023
DOIs	https://doi.org/10.1111/cdev.13914
Publication status	Published - 1 Jul 2023

Bibliographical note

Copyright © 2023 The Authors. Child Development published by Wiley Periodicals LLC on behalf of Society for Research in Child Development.

This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

Research Funding: Silvia Paracchini and Filippo Abbondanza are funded by the Royal Society (UF150663; RGF\EA\180141). The UK Medical Research Council and Wellcome (Grant ref: 217065/Z/19/Z) and the University of Bristol provide
core support for ALSPAC. This publication is the work of the authors and will serve as guarantors for the contents of this paper. A comprehensive list of grants funding is available on the ALSPAC website: http://www.brist
ol.ac.uk/alspa c/exter nal/docum ents/grant-acknowledgements.pdf. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. Elsje van Bergen was supported
by NWO VENI fellowship 451-15- 017. Support for the Toronto cohort collection was provided by grants from the Canadian Institutes of Health Research (MOP-133440). K.M.P. was supported by the Hospital for Sick Children
Research Training Program (Restracomp). Simon Fisher is funded by the Max Planck Society. Dorothy Bishop is funded by European Research Council Advanced Grant 694189. Andrew Whitehouse is supported by an Investigator Grant from the National Health and Medical Research Council (1173896). The Raine Study was supported by the National Health and Medical Research Council of Australia (grant numbers 572613, 403981, 1059711), and the Canadian Institutes of Health Research (grant number MOP-82893). The Multicenter
Study Marburg/Würzburg cohort was funded by the Deutsche Forschungsgemeinschaft (DFG).

Access to Document

10.1111/cdev.13914Licence: CC BY 4.0

cdev.13914.pdf
Copyright © 2023 The Authors. Child Development published by Wiley Periodicals LLC on behalf of Society for Research in Child Development. This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
Final published version, 1.14 MBLicence: CC BY 4.0

Cite this

Abbondanza, F., Dale, P. S., Wang, C. A., Hayiou‐Thomas, M. E., Toseeb, U., Koomar, T. S., Wigg, K. G., Feng, Y., Price, K. M., Kerr, E. N., Guger, S. L., Lovett, M. W., Strug, L. J., van Bergen, E., Dolan, C. V., Tomblin, J. B., Moll, K., Schulte‐Körne, G., Neuhoff, N., ... Paracchini, S. (2023). Language and reading impairments are associated with increased prevalence of non‐right‐handedness. Child Development, 94(4), 970-984. https://doi.org/10.1111/cdev.13914

@article{bc390fc4a02b41628dd2a8f1b77d6a96,

title = "Language and reading impairments are associated with increased prevalence of non‐right‐handedness",

abstract = "Handedness has been studied for association with language‐related disorders because of its link with language hemispheric dominance. No clear pattern has emerged, possibly because of small samples, publication bias, and heterogeneous criteria across studies. Non‐right‐handedness (NRH) frequency was assessed in N = 2503 cases with reading and/or language impairment and N = 4316 sex‐matched controls identified from 10 distinct cohorts (age range 6–19 years old; European ethnicity) using a priori set criteria. A meta‐analysis (Ncases = 1994) showed elevated NRH \% in individuals with language/reading impairment compared with controls (OR = 1.21, CI = 1.06–1.39, p = .01). The association between reading/language impairments and NRH could result from shared pathways underlying brain lateralization, handedness, and cognitive functions.",

author = "Filippo Abbondanza and Dale, \{Philip S.\} and Wang, \{Carol A.\} and Hayiou‐Thomas, \{Marianna E.\} and Umar Toseeb and Koomar, \{Tanner S.\} and Wigg, \{Karen G.\} and Yu Feng and Price, \{Kaitlyn M.\} and Kerr, \{Elizabeth N.\} and Guger, \{Sharon L.\} and Lovett, \{Maureen W.\} and Strug, \{Lisa J.\} and \{van Bergen\}, Elsje and Dolan, \{Conor V.\} and Tomblin, \{J. Bruce\} and Kristina Moll and Gerd Schulte‐K{\"o}rne and Nina Neuhoff and Andreas Warnke and Fisher, \{Simon E.\} and Barr, \{Cathy L.\} and Michaelson, \{Jacob J.\} and Boomsma, \{Dorret I.\} and Snowling, \{Margaret J.\} and Charles Hulme and Whitehouse, \{Andrew J. O.\} and Pennell, \{Craig E.\} and Newbury, \{Dianne F.\} and John Stein and Talcott, \{Joel B.\} and Bishop, \{Dorothy V. M.\} and Silvia Paracchini",

note = "Copyright {\textcopyright} 2023 The Authors. Child Development published by Wiley Periodicals LLC on behalf of Society for Research in Child Development. This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited. Research Funding: Silvia Paracchini and Filippo Abbondanza are funded by the Royal Society (UF150663; RGF\textbackslash{}EA\textbackslash{}180141). The UK Medical Research Council and Wellcome (Grant ref: 217065/Z/19/Z) and the University of Bristol provide core support for ALSPAC. This publication is the work of the authors and will serve as guarantors for the contents of this paper. A comprehensive list of grants funding is available on the ALSPAC website: http://www.brist ol.ac.uk/alspa c/exter nal/docum ents/grant-acknowledgements.pdf. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. Elsje van Bergen was supported by NWO VENI fellowship 451-15- 017. Support for the Toronto cohort collection was provided by grants from the Canadian Institutes of Health Research (MOP-133440). K.M.P. was supported by the Hospital for Sick Children Research Training Program (Restracomp). Simon Fisher is funded by the Max Planck Society. Dorothy Bishop is funded by European Research Council Advanced Grant 694189. Andrew Whitehouse is supported by an Investigator Grant from the National Health and Medical Research Council (1173896). The Raine Study was supported by the National Health and Medical Research Council of Australia (grant numbers 572613, 403981, 1059711), and the Canadian Institutes of Health Research (grant number MOP-82893). The Multicenter Study Marburg/W{\"u}rzburg cohort was funded by the Deutsche Forschungsgemeinschaft (DFG).",

year = "2023",

month = jul,

day = "1",

doi = "10.1111/cdev.13914",

language = "English",

volume = "94",

pages = "970--984",

journal = "Child Development",

issn = "0009-3920",

publisher = "Wiley-Blackwell",

number = "4",

}

Abbondanza, F, Dale, PS, Wang, CA, Hayiou‐Thomas, ME, Toseeb, U, Koomar, TS, Wigg, KG, Feng, Y, Price, KM, Kerr, EN, Guger, SL, Lovett, MW, Strug, LJ, van Bergen, E, Dolan, CV, Tomblin, JB, Moll, K, Schulte‐Körne, G, Neuhoff, N, Warnke, A, Fisher, SE, Barr, CL, Michaelson, JJ, Boomsma, DI, Snowling, MJ, Hulme, C, Whitehouse, AJO, Pennell, CE, Newbury, DF, Stein, J, Talcott, JB, Bishop, DVM & Paracchini, S 2023, 'Language and reading impairments are associated with increased prevalence of non‐right‐handedness', Child Development, vol. 94, no. 4, pp. 970-984. https://doi.org/10.1111/cdev.13914

TY - JOUR

T1 - Language and reading impairments are associated with increased prevalence of non‐right‐handedness

AU - Abbondanza, Filippo

AU - Dale, Philip S.

AU - Wang, Carol A.

AU - Hayiou‐Thomas, Marianna E.

AU - Toseeb, Umar

AU - Koomar, Tanner S.

AU - Wigg, Karen G.

AU - Feng, Yu

AU - Price, Kaitlyn M.

AU - Kerr, Elizabeth N.

AU - Guger, Sharon L.

AU - Lovett, Maureen W.

AU - Strug, Lisa J.

AU - van Bergen, Elsje

AU - Dolan, Conor V.

AU - Tomblin, J. Bruce

AU - Moll, Kristina

AU - Schulte‐Körne, Gerd

AU - Neuhoff, Nina

AU - Warnke, Andreas

AU - Fisher, Simon E.

AU - Barr, Cathy L.

AU - Michaelson, Jacob J.

AU - Boomsma, Dorret I.

AU - Snowling, Margaret J.

AU - Hulme, Charles

AU - Whitehouse, Andrew J. O.

AU - Pennell, Craig E.

AU - Newbury, Dianne F.

AU - Stein, John

AU - Talcott, Joel B.

AU - Bishop, Dorothy V. M.

AU - Paracchini, Silvia

N1 - Copyright © 2023 The Authors. Child Development published by Wiley Periodicals LLC on behalf of Society for Research in Child Development. This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited. Research Funding: Silvia Paracchini and Filippo Abbondanza are funded by the Royal Society (UF150663; RGF\EA\180141). The UK Medical Research Council and Wellcome (Grant ref: 217065/Z/19/Z) and the University of Bristol provide core support for ALSPAC. This publication is the work of the authors and will serve as guarantors for the contents of this paper. A comprehensive list of grants funding is available on the ALSPAC website: http://www.brist ol.ac.uk/alspa c/exter nal/docum ents/grant-acknowledgements.pdf. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. Elsje van Bergen was supported by NWO VENI fellowship 451-15- 017. Support for the Toronto cohort collection was provided by grants from the Canadian Institutes of Health Research (MOP-133440). K.M.P. was supported by the Hospital for Sick Children Research Training Program (Restracomp). Simon Fisher is funded by the Max Planck Society. Dorothy Bishop is funded by European Research Council Advanced Grant 694189. Andrew Whitehouse is supported by an Investigator Grant from the National Health and Medical Research Council (1173896). The Raine Study was supported by the National Health and Medical Research Council of Australia (grant numbers 572613, 403981, 1059711), and the Canadian Institutes of Health Research (grant number MOP-82893). The Multicenter Study Marburg/Würzburg cohort was funded by the Deutsche Forschungsgemeinschaft (DFG).

PY - 2023/7/1

Y1 - 2023/7/1

N2 - Handedness has been studied for association with language‐related disorders because of its link with language hemispheric dominance. No clear pattern has emerged, possibly because of small samples, publication bias, and heterogeneous criteria across studies. Non‐right‐handedness (NRH) frequency was assessed in N = 2503 cases with reading and/or language impairment and N = 4316 sex‐matched controls identified from 10 distinct cohorts (age range 6–19 years old; European ethnicity) using a priori set criteria. A meta‐analysis (Ncases = 1994) showed elevated NRH % in individuals with language/reading impairment compared with controls (OR = 1.21, CI = 1.06–1.39, p = .01). The association between reading/language impairments and NRH could result from shared pathways underlying brain lateralization, handedness, and cognitive functions.

AB - Handedness has been studied for association with language‐related disorders because of its link with language hemispheric dominance. No clear pattern has emerged, possibly because of small samples, publication bias, and heterogeneous criteria across studies. Non‐right‐handedness (NRH) frequency was assessed in N = 2503 cases with reading and/or language impairment and N = 4316 sex‐matched controls identified from 10 distinct cohorts (age range 6–19 years old; European ethnicity) using a priori set criteria. A meta‐analysis (Ncases = 1994) showed elevated NRH % in individuals with language/reading impairment compared with controls (OR = 1.21, CI = 1.06–1.39, p = .01). The association between reading/language impairments and NRH could result from shared pathways underlying brain lateralization, handedness, and cognitive functions.

UR - https://srcd.onlinelibrary.wiley.com/doi/10.1111/cdev.13914

UR - https://www.scopus.com/pages/publications/85147989705

U2 - 10.1111/cdev.13914

DO - 10.1111/cdev.13914

M3 - Article

C2 - 36780127

SN - 0009-3920

VL - 94

SP - 970

EP - 984

JO - Child Development

JF - Child Development

IS - 4

ER -

Language and reading impairments are associated with increased prevalence of non‐right‐handedness

Abstract

Bibliographical note

Access to Document

Other files and links

Fingerprint

Cite this