Research output per year
Research output per year
Nagamani Bora*
Research output: Chapter in Book/Published conference output › Chapter (peer-reviewed) › peer-review
The production of recombinant therapeutic proteins is an active area of research in drug development. These bio-therapeutic drugs target nearly 150 disease states and promise to bring better treatments to patients. However, if new bio-therapeutics are to be made more accessible and affordable, improvements in production performance and optimization of processes are necessary. A major challenge lies in controlling the effect of process conditions on production of intact functional proteins. To achieve this, improved tools are needed for bio-processing. For example, implementation of process modeling and high-throughput technologies can be used to achieve quality by design, leading to improvements in productivity. Commercially, the most sought after targets are secreted proteins due to the ease of handling in downstream procedures. This chapter outlines different approaches for production and optimization of secreted proteins in the host Pichia pastoris.
Original language | English |
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Title of host publication | Recombinant protein production in yeast |
Editors | Roslyn M. Bill |
Publisher | Humana Press |
Pages | 217-235 |
Number of pages | 19 |
ISBN (Electronic) | 978-1-61779-770-5 |
ISBN (Print) | 978-1-61779-769-9 |
DOIs | |
Publication status | Published - 25 Feb 2012 |
Name | Methods in molecular biology |
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Publisher | Humana Press |
Volume | 866 |
ISSN (Print) | 1064-3745 |
Name | Springer protocols |
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Publisher | Springer |
Research output: Chapter in Book/Published conference output › Chapter (peer-reviewed) › peer-review
Research output: Chapter in Book/Published conference output › Chapter (peer-reviewed) › peer-review
Research output: Chapter in Book/Published conference output › Foreword/postscript