Leptin decreases apoptosis and alters BCL-2: bax ratio in clonal rodent pancreatic beta-cells

James E.P. Brown; Simon J. Dunmore

doi:10.1002/dmrr.726

Leptin decreases apoptosis and alters BCL-2: bax ratio in clonal rodent pancreatic beta-cells

James E.P. Brown, Simon J. Dunmore

Research output: Contribution to journal › Article › peer-review

Abstract

The adipocyte derived peptide hormone leptin is known to regulate apoptosis and cell viability in several cells and tissues, as well as having several pancreatic islet beta-cell specific effects such as inhibition of glucose-stimulated insulin secretion. This study investigated the effects of leptin upon apoptosis induced by serum depletion and on expression of the apoptotic regulators B-cell leukaemia 2 gene product (BCL-2) and BCL2-associated X protein (Bax) in the glucose-responsive BRIN-BD11 beta-cell line.

Original language	English
Pages (from-to)	497-502
Number of pages	6
Journal	Diabetes/Metabolism Research and Reviews
Volume	23
Issue number	6
Early online date	22 Feb 2007
DOIs	https://doi.org/10.1002/dmrr.726
Publication status	Published - Sept 2007

Keywords

immunoglobulin enhancer binding protein
leptin
messenger RNA
protein Bax
protein bcl 2

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10.1002/dmrr.726

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abstract = "The adipocyte derived peptide hormone leptin is known to regulate apoptosis and cell viability in several cells and tissues, as well as having several pancreatic islet beta-cell specific effects such as inhibition of glucose-stimulated insulin secretion. This study investigated the effects of leptin upon apoptosis induced by serum depletion and on expression of the apoptotic regulators B-cell leukaemia 2 gene product (BCL-2) and BCL2-associated X protein (Bax) in the glucose-responsive BRIN-BD11 beta-cell line.",

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author = "Brown, {James E.P.} and Dunmore, {Simon J.}",

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AB - The adipocyte derived peptide hormone leptin is known to regulate apoptosis and cell viability in several cells and tissues, as well as having several pancreatic islet beta-cell specific effects such as inhibition of glucose-stimulated insulin secretion. This study investigated the effects of leptin upon apoptosis induced by serum depletion and on expression of the apoptotic regulators B-cell leukaemia 2 gene product (BCL-2) and BCL2-associated X protein (Bax) in the glucose-responsive BRIN-BD11 beta-cell line.

KW - immunoglobulin enhancer binding protein

KW - leptin

KW - messenger RNA

KW - protein Bax

KW - protein bcl 2

UR - http://onlinelibrary.wiley.com/doi/10.1002/dmrr.726/abstract

U2 - 10.1002/dmrr.726

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JO - Diabetes/Metabolism Research and Reviews

JF - Diabetes/Metabolism Research and Reviews

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ER -

Leptin decreases apoptosis and alters BCL-2: bax ratio in clonal rodent pancreatic beta-cells

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Keywords

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