Leptin decreases apoptosis and alters BCL-2: bax ratio in clonal rodent pancreatic beta-cells

James E.P. Brown, Simon J. Dunmore

Research output: Contribution to journalArticlepeer-review

Abstract

The adipocyte derived peptide hormone leptin is known to regulate apoptosis and cell viability in several cells and tissues, as well as having several pancreatic islet beta-cell specific effects such as inhibition of glucose-stimulated insulin secretion. This study investigated the effects of leptin upon apoptosis induced by serum depletion and on expression of the apoptotic regulators B-cell leukaemia 2 gene product (BCL-2) and BCL2-associated X protein (Bax) in the glucose-responsive BRIN-BD11 beta-cell line.
Original languageEnglish
Pages (from-to)497-502
Number of pages6
JournalDiabetes/Metabolism Research and Reviews
Volume23
Issue number6
Early online date22 Feb 2007
DOIs
Publication statusPublished - Sep 2007

Keywords

  • immunoglobulin enhancer binding protein
  • leptin
  • messenger RNA
  • protein Bax
  • protein bcl 2

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