Lewy body and Alzheimer pathology in temporal lobe in dementia with Lewy bodies

Richard A. Armstrong, N.J. Cairns, P.L. Lantos

Research output: Contribution to journalArticlepeer-review


The density of Lewy bodies (LB), senile plaques (SP), and neurofibrillary tangles (NFT) was studied in the temporal lobe in four patients diagnosed with ‘pure’ dementia with Lewy bodies (DLB) and eight patients diagnosed with DLB with associated Alzheimer’s disease (DLB/AD). In both patient groups, the density of LB was greatest in the lateral occipitotemporal gyrus (LOT) and least in areaas CA1 and CA4 of the hippocampus. In DLB/AD, the densities of SP and NFT were greatest in the cortical regions and in area CA1 of the hippocampus respectively. Mean LB densities in the temporal lobe were similar in ‘pure’ DLB and DLB/AD patients but mean SP and NFT densities were greater in DLB/AD. No significant correlations were observed between the densities of LB, SP and NFT in any brain region. The data suggest that in the temporal lobe LB and SP/NFT are distributed differently; SP and NFT in DLB/AD are distributed similarly to ‘pure’ AD and also that LB and AD pathologies appear to develop independently. Hence, the data support the hypothesis that some cases of DLB combine the features of DLB and AD.
Original languageEnglish
Pages (from-to)159-163
Number of pages5
JournalAlzheimers Reports
Issue number3
Publication statusPublished - 1998


  • Alzheimer’s disease
  • dementia
  • Lewy bodies
  • neurofibrillary tangles
  • senile plaques
  • temporal lobe
  • ubiquitin


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