Limb-state information encoded by peripheral and central somatosensory neurons:   Implications for an afferent interface

Douglas J. Weber; Brian M. London; James A. Hokanson; Christopher A. Ayers; Robert A. Gaunt; Ricardo R. Torres; Boubker Zaaimi; Lee E. Miller

doi:10.1109/TNSRE.2011.2163145

Limb-state information encoded by peripheral and central somatosensory neurons: Implications for an afferent interface

Douglas J. Weber^*
, Brian M. London
, James A. Hokanson
, Christopher A. Ayers
, Robert A. Gaunt
, Ricardo R. Torres
, Boubker Zaaimi
, Lee E. Miller

^*Corresponding author for this work

University of Pittsburgh
Northwestern University, Evanston

Research output: Contribution to journal › Article › peer-review

83 Citations (SciVal)

57 Downloads (Pure)

Abstract

A major issue to be addressed in the development of neural interfaces for prosthetic control is the need for somatosensory feedback. Here, we investigate two possible strategies: electrical stimulation of either dorsal root ganglia (DRG) or primary somatosensory cortex (S1). In each approach, we must determine a model that reflects the representation of limb state in terms of neural discharge. This model can then be used to design stimuli that artificially activate the nervous system to convey information about limb state to the subject. Electrically activating DRG neurons using naturalistic stimulus patterns, modeled on recordings made during passive limb movement, evoked activity in S1 that was similar to that of the original movement. We also found that S1 neural populations could accurately discriminate different patterns of DRG stimulation across a wide range of stimulus pulse-rates. In studying the neural coding in S1, we also decoded the kinematics of active limb movement using multi-electrode recordings in the monkey. Neurons having both proprioceptive and cutaneous receptive fields contributed equally to this decoding. Some neurons were most informative of limb state in the recent past, but many others appeared to signal upcoming movements suggesting that they also were modulated by an efference copy signal. Finally, we show that a monkey was able to detect stimulation through a large percentage of electrodes implanted in area 2. We discuss the design of appropriate stimulus paradigms for conveying time-varying limb state information, and the relative merits and limitations of central and peripheral approaches.

Original language	English
Article number	5999720
Pages (from-to)	501-513
Number of pages	13
Journal	IEEE Transactions on Neural Systems and Rehabilitation Engineering
Volume	19
Issue number	5
DOIs	https://doi.org/10.1109/TNSRE.2011.2163145
Publication status	Published - 1 Oct 2011

Bibliographical note

© 2011 IEEE. Personal use of this material is permitted. Permission from IEEE must be obtained for all other uses, in any current or future media, including reprinting/republishing this material for advertising or promotional purposes, creating new collective works, for resale or redistribution to servers or lists, or reuse of any copyrighted component of this work in other works.

Funding

Manuscript received February 12, 2011; revised May 16, 2011; accepted July 03, 2011. Date of publication August 30, 2011; date of current version October 07, 2011. The work of D. J. Weber was supported in part by the National Institutes of Health (NIH) under Grant 1R01-EB007749 and Grant 1R21-NS-056136, and in part by TATRC under Grant W81XWH-07-1-0716. The work of L. E. Miller was supported by the NIH under Grant1R01-NS048845.

Keywords

Dorsal root ganglia
multielectrode array
neural coding
neural prostheses
sensory cortex
sensory feedback
somatosensory

Access to Document

10.1109/TNSRE.2011.2163145

Limb-state information encoded by peripheral and central somatosensory neurons
© 2011 IEEE. Personal use of this material is permitted. Permission from IEEE must be obtained for all other uses, in any current or future media, including reprinting/republishing this material for advertising or promotional purposes, creating new collective works, for resale or redistribution to servers or lists, or reuse of any copyrighted component of this work in other works.
Accepted author manuscript, 1.49 MB

Cite this

Weber, D. J., London, B. M., Hokanson, J. A., Ayers, C. A., Gaunt, R. A., Torres, R. R., Zaaimi, B., & Miller, L. E. (2011). Limb-state information encoded by peripheral and central somatosensory neurons: Implications for an afferent interface. IEEE Transactions on Neural Systems and Rehabilitation Engineering, 19(5), 501-513. Article 5999720. https://doi.org/10.1109/TNSRE.2011.2163145

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note = "{\textcopyright} 2011 IEEE. Personal use of this material is permitted. Permission from IEEE must be obtained for all other uses, in any current or future media, including reprinting/republishing this material for advertising or promotional purposes, creating new collective works, for resale or redistribution to servers or lists, or reuse of any copyrighted component of this work in other works.",

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Weber, DJ, London, BM, Hokanson, JA, Ayers, CA, Gaunt, RA, Torres, RR, Zaaimi, B & Miller, LE 2011, 'Limb-state information encoded by peripheral and central somatosensory neurons: Implications for an afferent interface', IEEE Transactions on Neural Systems and Rehabilitation Engineering, vol. 19, no. 5, 5999720, pp. 501-513. https://doi.org/10.1109/TNSRE.2011.2163145

Limb-state information encoded by peripheral and central somatosensory neurons: Implications for an afferent interface. / Weber, Douglas J.; London, Brian M.; Hokanson, James A. et al.
In: IEEE Transactions on Neural Systems and Rehabilitation Engineering, Vol. 19, No. 5, 5999720, 01.10.2011, p. 501-513.

Research output: Contribution to journal › Article › peer-review

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