Limitations of the isolated GP-STN network

Ian M. Stanford; K.C. Loucif; Clare L. Wilson; D. Cash; M.G. Lacey

doi:10.1007/0-387-28066-9_6

Limitations of the isolated GP-STN network

Ian M. Stanford, K.C. Loucif, Clare L. Wilson, D. Cash, M.G. Lacey

Research output: Chapter in Book/Published conference output › Chapter

Abstract

An in vitro mouse slice preparation from control and MPTP-treated mice in which functional reciprocal GP-STN connectivity is maintained, does not produce oscillatory bursting or synchronous activity neuronal activity. Pharmacological interventions that produce bursting activity do so without concomitant neuronal synchrony, or a requirement for glutamate or GABA transmission. Pre-treatment with MPTP did not alter this behaviour. Thus, we have no evidence that the functionally connected, but isolated, GP — STN network can act as a pacemaker for synchronous correlated activity in the basal ganglia and must conclude that other inputs such as those from cortex and/or striatum are required.

Original language	English
Title of host publication	The Basal Ganglia VIII
Editors	J.P. Bolam, C.A. Ingham, P.J. Magill
Place of Publication	New York (US)
Publisher	Springer
Pages	65-73
Number of pages	9
Volume	8
ISBN (Print)	9780387280653
DOIs	https://doi.org/10.1007/0-387-28066-9_6
Publication status	Published - 25 Dec 2005
Event	Basal Ganglia VIII - Duration: 25 Dec 2005 → 25 Dec 2005

Publication series

Name	Advances in Behavioral Biology
Publisher	Springer
Volume	56

Conference

Conference	Basal Ganglia VIII
Period	25/12/05 → 25/12/05

Bibliographical note

8th Triennial Meeting of the International-Basal-Ganglia-Society, Crieff, Scotland, 5-9 September 2004

Access to Document

10.1007/0-387-28066-9_6

LIMITATIONS OF THE ISOLATED GP-STN NETWORK
8th Triennial Meeting of the International-Basal-Ganglia-Society, Crieff, Scotland, 5-9 September 2004
Accepted author manuscript, 383 KB

Cite this

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abstract = "An in vitro mouse slice preparation from control and MPTP-treated mice in which functional reciprocal GP-STN connectivity is maintained, does not produce oscillatory bursting or synchronous activity neuronal activity. Pharmacological interventions that produce bursting activity do so without concomitant neuronal synchrony, or a requirement for glutamate or GABA transmission. Pre-treatment with MPTP did not alter this behaviour. Thus, we have no evidence that the functionally connected, but isolated, GP — STN network can act as a pacemaker for synchronous correlated activity in the basal ganglia and must conclude that other inputs such as those from cortex and/or striatum are required.",

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AU - Loucif, K.C.

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AU - Cash, D.

AU - Lacey, M.G.

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Y2 - 25 December 2005 through 25 December 2005

ER -

Limitations of the isolated GP-STN network

Abstract

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Bibliographical note

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