Limitations of the isolated GP-STN network

Ian M. Stanford, K.C. Loucif, Clare L. Wilson, D. Cash, M.G. Lacey

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

An in vitro mouse slice preparation from control and MPTP-treated mice in which functional reciprocal GP-STN connectivity is maintained, does not produce oscillatory bursting or synchronous activity neuronal activity. Pharmacological interventions that produce bursting activity do so without concomitant neuronal synchrony, or a requirement for glutamate or GABA transmission. Pre-treatment with MPTP did not alter this behaviour. Thus, we have no evidence that the functionally connected, but isolated, GP — STN network can act as a pacemaker for synchronous correlated activity in the basal ganglia and must conclude that other inputs such as those from cortex and/or striatum are required.
Original languageEnglish
Title of host publicationThe Basal Ganglia VIII
EditorsJ.P. Bolam, C.A. Ingham, P.J. Magill
Place of PublicationNew York (US)
PublisherSpringer
Pages65-73
Number of pages9
Volume8
ISBN (Print)9780387280653
DOIs
Publication statusPublished - 25 Dec 2005
EventBasal Ganglia VIII -
Duration: 25 Dec 200525 Dec 2005

Publication series

NameAdvances in Behavioral Biology
PublisherSpringer
Volume56

Conference

ConferenceBasal Ganglia VIII
Period25/12/0525/12/05

Fingerprint

1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine
Basal Ganglia
gamma-Aminobutyric Acid
Glutamic Acid
Pharmacology
In Vitro Techniques

Bibliographical note

8th Triennial Meeting of the International-Basal-Ganglia-Society, Crieff, Scotland, 5-9 September 2004

Cite this

Stanford, I. M., Loucif, K. C., Wilson, C. L., Cash, D., & Lacey, M. G. (2005). Limitations of the isolated GP-STN network. In J. P. Bolam, C. A. Ingham, & P. J. Magill (Eds.), The Basal Ganglia VIII (Vol. 8, pp. 65-73). (Advances in Behavioral Biology; Vol. 56). New York (US): Springer. https://doi.org/10.1007/0-387-28066-9_6
Stanford, Ian M. ; Loucif, K.C. ; Wilson, Clare L. ; Cash, D. ; Lacey, M.G. / Limitations of the isolated GP-STN network. The Basal Ganglia VIII. editor / J.P. Bolam ; C.A. Ingham ; P.J. Magill. Vol. 8 New York (US) : Springer, 2005. pp. 65-73 (Advances in Behavioral Biology).
@inbook{11a781d0af7f4bf9b8b764e03e34efaf,
title = "Limitations of the isolated GP-STN network",
abstract = "An in vitro mouse slice preparation from control and MPTP-treated mice in which functional reciprocal GP-STN connectivity is maintained, does not produce oscillatory bursting or synchronous activity neuronal activity. Pharmacological interventions that produce bursting activity do so without concomitant neuronal synchrony, or a requirement for glutamate or GABA transmission. Pre-treatment with MPTP did not alter this behaviour. Thus, we have no evidence that the functionally connected, but isolated, GP — STN network can act as a pacemaker for synchronous correlated activity in the basal ganglia and must conclude that other inputs such as those from cortex and/or striatum are required.",
author = "Stanford, {Ian M.} and K.C. Loucif and Wilson, {Clare L.} and D. Cash and M.G. Lacey",
note = "8th Triennial Meeting of the International-Basal-Ganglia-Society, Crieff, Scotland, 5-9 September 2004",
year = "2005",
month = "12",
day = "25",
doi = "10.1007/0-387-28066-9_6",
language = "English",
isbn = "9780387280653",
volume = "8",
series = "Advances in Behavioral Biology",
publisher = "Springer",
pages = "65--73",
editor = "J.P. Bolam and C.A. Ingham and P.J. Magill",
booktitle = "The Basal Ganglia VIII",
address = "Germany",

}

Stanford, IM, Loucif, KC, Wilson, CL, Cash, D & Lacey, MG 2005, Limitations of the isolated GP-STN network. in JP Bolam, CA Ingham & PJ Magill (eds), The Basal Ganglia VIII. vol. 8, Advances in Behavioral Biology, vol. 56, Springer, New York (US), pp. 65-73, Basal Ganglia VIII, 25/12/05. https://doi.org/10.1007/0-387-28066-9_6

Limitations of the isolated GP-STN network. / Stanford, Ian M.; Loucif, K.C.; Wilson, Clare L.; Cash, D.; Lacey, M.G.

The Basal Ganglia VIII. ed. / J.P. Bolam; C.A. Ingham; P.J. Magill. Vol. 8 New York (US) : Springer, 2005. p. 65-73 (Advances in Behavioral Biology; Vol. 56).

Research output: Chapter in Book/Report/Conference proceedingChapter

TY - CHAP

T1 - Limitations of the isolated GP-STN network

AU - Stanford, Ian M.

AU - Loucif, K.C.

AU - Wilson, Clare L.

AU - Cash, D.

AU - Lacey, M.G.

N1 - 8th Triennial Meeting of the International-Basal-Ganglia-Society, Crieff, Scotland, 5-9 September 2004

PY - 2005/12/25

Y1 - 2005/12/25

N2 - An in vitro mouse slice preparation from control and MPTP-treated mice in which functional reciprocal GP-STN connectivity is maintained, does not produce oscillatory bursting or synchronous activity neuronal activity. Pharmacological interventions that produce bursting activity do so without concomitant neuronal synchrony, or a requirement for glutamate or GABA transmission. Pre-treatment with MPTP did not alter this behaviour. Thus, we have no evidence that the functionally connected, but isolated, GP — STN network can act as a pacemaker for synchronous correlated activity in the basal ganglia and must conclude that other inputs such as those from cortex and/or striatum are required.

AB - An in vitro mouse slice preparation from control and MPTP-treated mice in which functional reciprocal GP-STN connectivity is maintained, does not produce oscillatory bursting or synchronous activity neuronal activity. Pharmacological interventions that produce bursting activity do so without concomitant neuronal synchrony, or a requirement for glutamate or GABA transmission. Pre-treatment with MPTP did not alter this behaviour. Thus, we have no evidence that the functionally connected, but isolated, GP — STN network can act as a pacemaker for synchronous correlated activity in the basal ganglia and must conclude that other inputs such as those from cortex and/or striatum are required.

UR - http://www.springerlink.com/content/q8552v5245288g87/?p=3328909f99c844c3b08620cead144484&pi=5

U2 - 10.1007/0-387-28066-9_6

DO - 10.1007/0-387-28066-9_6

M3 - Chapter

SN - 9780387280653

VL - 8

T3 - Advances in Behavioral Biology

SP - 65

EP - 73

BT - The Basal Ganglia VIII

A2 - Bolam, J.P.

A2 - Ingham, C.A.

A2 - Magill, P.J.

PB - Springer

CY - New York (US)

ER -

Stanford IM, Loucif KC, Wilson CL, Cash D, Lacey MG. Limitations of the isolated GP-STN network. In Bolam JP, Ingham CA, Magill PJ, editors, The Basal Ganglia VIII. Vol. 8. New York (US): Springer. 2005. p. 65-73. (Advances in Behavioral Biology). https://doi.org/10.1007/0-387-28066-9_6