Liquid-liquid phase equilibria in nicotine (aqueous) solutions

N.D. Grozdanic, V. Najdanovic-Visak, M.L.J. Kijevcanin, S.P. Serbanovic, M. Nunes da Ponte, Z.P. Visak

Research output: Contribution to journalArticle

Abstract

Liquid–liquid equilibria were measured for solutions containing: (1) nicotine, and one of the solvents PEG 200 or ethyl-lactate, and the ionic liquid 1-ethyl-3-methylimidazolium ethyl sulphate (ECOENG 212®); (2) a (nicotine + water) mixture of close to critical composition and one of the co-solvents PEG 200, or glycerol, or ethyl-lactate; and (3) a (nicotine + water) mixture and one of the salts ECOENG 212®, or sodium chloride, or sodium phosphate. The objective of these measurements was to assess the possibility of using environmentally friendly solvents for extraction/separation of nicotine from its (aqueous) solutions. PEG 200, glycerol and ethyl-lactate proved to be good co-solvents of nicotine in water. On the other hand, the inorganic salts Na3PO4 and NaCl showed remarkable salting-out effects in nicotine aqueous solutions, achieved using very small quantities of these salt. The effects of the ionic liquid (molten salt) ECOENG 212®, were, however, much more complex. Depending on its concentration in the solvent, it exhibited either a co-solvent (salting-in) effect or an anti-solvent one. This behaviour is very interesting both from the fundamental and the applications point of view.
Original languageEnglish
Pages (from-to)198-206
JournalFluid Phase Equilibria
Volume310
Issue number1-2
DOIs
Publication statusPublished - 25 Nov 2011

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nicotine
Nicotine
Phase equilibria
liquid phases
aqueous solutions
Liquids
lactates
liquids
Salts
Polyethylene glycols
Ionic Liquids
glycerols
salts
Glycerol
Ionic liquids
Water
water
molten salts
sodium chlorides
Sodium chloride

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Grozdanic, N. D., Najdanovic-Visak, V., Kijevcanin, M. L. J., Serbanovic, S. P., Nunes da Ponte, M., & Visak, Z. P. (2011). Liquid-liquid phase equilibria in nicotine (aqueous) solutions. Fluid Phase Equilibria, 310(1-2), 198-206. https://doi.org/10.1016/j.fluid.2011.08.022
Grozdanic, N.D. ; Najdanovic-Visak, V. ; Kijevcanin, M.L.J. ; Serbanovic, S.P. ; Nunes da Ponte, M. ; Visak, Z.P. / Liquid-liquid phase equilibria in nicotine (aqueous) solutions. In: Fluid Phase Equilibria. 2011 ; Vol. 310, No. 1-2. pp. 198-206.
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Grozdanic, ND, Najdanovic-Visak, V, Kijevcanin, MLJ, Serbanovic, SP, Nunes da Ponte, M & Visak, ZP 2011, 'Liquid-liquid phase equilibria in nicotine (aqueous) solutions', Fluid Phase Equilibria, vol. 310, no. 1-2, pp. 198-206. https://doi.org/10.1016/j.fluid.2011.08.022

Liquid-liquid phase equilibria in nicotine (aqueous) solutions. / Grozdanic, N.D.; Najdanovic-Visak, V.; Kijevcanin, M.L.J.; Serbanovic, S.P.; Nunes da Ponte, M.; Visak, Z.P.

In: Fluid Phase Equilibria, Vol. 310, No. 1-2, 25.11.2011, p. 198-206.

Research output: Contribution to journalArticle

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AU - Grozdanic, N.D.

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AU - Nunes da Ponte, M.

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Grozdanic ND, Najdanovic-Visak V, Kijevcanin MLJ, Serbanovic SP, Nunes da Ponte M, Visak ZP. Liquid-liquid phase equilibria in nicotine (aqueous) solutions. Fluid Phase Equilibria. 2011 Nov 25;310(1-2):198-206. https://doi.org/10.1016/j.fluid.2011.08.022