Macro- and Microvascular Function in Middle-Aged Individuals with Low Cardiovascular Disease Risk

Sunni Patel; Hala Shokr; Adam Greenstein; Doina Gherghel; Roberto Pedrinelli

doi:10.3390/jcm11236962

Macro- and Microvascular Function in Middle-Aged Individuals with Low Cardiovascular Disease Risk

Sunni Patel
, Hala Shokr
, Adam Greenstein
, Doina Gherghel^*
, Roberto Pedrinelli (Editor)

^*Corresponding author for this work

Optometry

Division of Cardiovascular Sciences, The University of Manchester, Manchester M13 9PL, UK

Research output: Contribution to journal › Article › peer-review

3 Citations (Scopus)

10 Downloads (Pure)

Abstract

Aims: To investigate the microvascular function in apparently healthy individuals showing signs of early macrovascular endothelial dysfunction. Methods: Healthy participants aged between 30–55 years were recruited for the present study. Baseline measurements included body-mass index (BMI), waist-to-hip ratio (WHR), 24-h blood pressure, as well as fasted venous glucose, triglycerides (TG) and cholesterol (HDL, LDL and total). Brachial artery reactivity was measured using the flow-mediated dilation (FMD) technique and retinal vessel reactivity was assessed by using the Dynamic Retinal Vessel Analyser (DVA) in all individuals. The enrolled participants were separated in two groups, based on either a reduced (group 1:

Original language	English
Article number	6962
Number of pages	9
Journal	Journal of Clinical Medicine
Volume	11
Issue number	23
Early online date	25 Nov 2022
DOIs	https://doi.org/10.3390/jcm11236962
Publication status	Published - Dec 2022

Bibliographical note

© 2022 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

microvascular function
retina
vascular endothelial
flow-mediated dilation

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jcm-11-06962-v2.pdf
© 2022 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
Final published version, 797 KBLicence: CC BY 4.0

Cite this

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abstract = "Aims: To investigate the microvascular function in apparently healthy individuals showing signs of early macrovascular endothelial dysfunction. Methods: Healthy participants aged between 30–55 years were recruited for the present study. Baseline measurements included body-mass index (BMI), waist-to-hip ratio (WHR), 24-h blood pressure, as well as fasted venous glucose, triglycerides (TG) and cholesterol (HDL, LDL and total). Brachial artery reactivity was measured using the flow-mediated dilation (FMD) technique and retinal vessel reactivity was assessed by using the Dynamic Retinal Vessel Analyser (DVA) in all individuals. The enrolled participants were separated in two groups, based on either a reduced (group 1: ",

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AU - Gherghel, Doina

A2 - Pedrinelli, Roberto

N1 - © 2022 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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KW - vascular endothelial

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Macro- and Microvascular Function in Middle-Aged Individuals with Low Cardiovascular Disease Risk

Abstract

Bibliographical note

UN SDGs

Keywords

Access to Document

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