Magnetoencephalography in the study of epilepsy and consciousness

Elaine Foley; Antonella Cerquiglini; Andrea Cavanna; Mable A. Nakubulwa; Paul L. Furlong; Caroline Witton; Stefano Seri

doi:10.1016/j.yebeh.2013.09.005

Magnetoencephalography in the study of epilepsy and consciousness

Elaine Foley, Antonella Cerquiglini, Andrea Cavanna, Mable A. Nakubulwa, Paul L. Furlong, Caroline Witton, Stefano Seri^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

Abstract

The neural bases of altered consciousness in patients with epilepsy during seizures and at rest have raised significant interest in the last decade. This exponential growth has been supported by the parallel development of techniques and methods to investigate brain function noninvasively with unprecedented spatial and temporal resolution. In this article, we review the contribution of magnetoencephalography to deconvolve the bioelectrical changes associated with impaired consciousness during seizures. We use data collected from a patient with refractory absence seizures to discuss how spike-wave discharges are associated with perturbations in optimal connectivity within and between brain regions and discuss indirect evidence to suggest that this phenomenon might explain the cognitive deficits experienced during prolonged 3/s spike-wave discharges. © 2013 Elsevier Inc.

Original language	English
Pages (from-to)	38-42
Number of pages	5
Journal	Epilepsy and Behavior
Volume	30
Early online date	7 Oct 2013
DOIs	https://doi.org/10.1016/j.yebeh.2013.09.005
Publication status	Published - 1 Jan 2014

Keywords

Absence seizures
Connectivity
Epilepsy
Magnetoencephalography
Phase lag index

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10.1016/j.yebeh.2013.09.005

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title = "Magnetoencephalography in the study of epilepsy and consciousness",

abstract = "The neural bases of altered consciousness in patients with epilepsy during seizures and at rest have raised significant interest in the last decade. This exponential growth has been supported by the parallel development of techniques and methods to investigate brain function noninvasively with unprecedented spatial and temporal resolution. In this article, we review the contribution of magnetoencephalography to deconvolve the bioelectrical changes associated with impaired consciousness during seizures. We use data collected from a patient with refractory absence seizures to discuss how spike-wave discharges are associated with perturbations in optimal connectivity within and between brain regions and discuss indirect evidence to suggest that this phenomenon might explain the cognitive deficits experienced during prolonged 3/s spike-wave discharges. {\textcopyright} 2013 Elsevier Inc.",

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T1 - Magnetoencephalography in the study of epilepsy and consciousness

AU - Foley, Elaine

AU - Cerquiglini, Antonella

AU - Cavanna, Andrea

AU - Nakubulwa, Mable A.

AU - Furlong, Paul L.

AU - Witton, Caroline

AU - Seri, Stefano

PY - 2014/1/1

Y1 - 2014/1/1

N2 - The neural bases of altered consciousness in patients with epilepsy during seizures and at rest have raised significant interest in the last decade. This exponential growth has been supported by the parallel development of techniques and methods to investigate brain function noninvasively with unprecedented spatial and temporal resolution. In this article, we review the contribution of magnetoencephalography to deconvolve the bioelectrical changes associated with impaired consciousness during seizures. We use data collected from a patient with refractory absence seizures to discuss how spike-wave discharges are associated with perturbations in optimal connectivity within and between brain regions and discuss indirect evidence to suggest that this phenomenon might explain the cognitive deficits experienced during prolonged 3/s spike-wave discharges. © 2013 Elsevier Inc.

AB - The neural bases of altered consciousness in patients with epilepsy during seizures and at rest have raised significant interest in the last decade. This exponential growth has been supported by the parallel development of techniques and methods to investigate brain function noninvasively with unprecedented spatial and temporal resolution. In this article, we review the contribution of magnetoencephalography to deconvolve the bioelectrical changes associated with impaired consciousness during seizures. We use data collected from a patient with refractory absence seizures to discuss how spike-wave discharges are associated with perturbations in optimal connectivity within and between brain regions and discuss indirect evidence to suggest that this phenomenon might explain the cognitive deficits experienced during prolonged 3/s spike-wave discharges. © 2013 Elsevier Inc.

KW - Absence seizures

KW - Connectivity

KW - Epilepsy

KW - Magnetoencephalography

KW - Phase lag index

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JO - Epilepsy and Behavior

JF - Epilepsy and Behavior

ER -

Magnetoencephalography in the study of epilepsy and consciousness

Abstract

Keywords

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