Manufacturing Exosomes: A Promising Therapeutic Platform

Ivano Luigi Colao, Randolph Corteling, Daniel Bracewell, Ivan Wall

Research output: Contribution to journalReview articlepeer-review


Extracellular vesicles, in particular the subclass exosomes, are rapidly emerging as a novel therapeutic platform. However, currently very few clinical validation studies and no clearly defined manufacturing process exist. As exosomes progress towards the clinic for treatment of a vast array of diseases, it is important to define the engineering basis for their manufacture early in the development cycle to ensure they can be produced cost-effectively at the appropriate scale. We hypothesize that transitioning to defined manufacturing platforms will increase consistency of the exosome product and improve their clinical advancement as a new therapeutic tool. We present manufacturing technologies and strategies that are being implemented and consider their application for the transition from bench-scale to clinical production of exosomes.

Original languageEnglish
Pages (from-to)242-256
Number of pages15
JournalTrends in Molecular Medicine
Issue number3
Early online date12 Feb 2018
Publication statusPublished - Mar 2018

Bibliographical note

© 2018, Elsevier. Licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International

Funding: Ministry of Education, Science and Technology (grant No. 2009-0093829). Engineering and Physical Science Research Council (EPSRC) Industrial Doctoral Training Centre in Bioprocess Engineering Leadership (EP/G034656/1).


  • exosomes;
  • regenerative medicine
  • process development
  • commercial manufacturing


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