Manufacturing methods for liposome adjuvants

Yvonne Perrie*, Elisabeth Kastner, Swapnil Khadke, Carla B. Roces, Peter Stone

*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

A wide range of studies have shown that liposomes can act as suitable adjuvants for a range of vaccine antigens. Properties such as their amphiphilic character and biphasic nature allow them to incorporate antigens within the lipid bilayer, on the surface, or encapsulated within the inner core. However, appropriate methods for the manufacture of liposomes are limited and this has resulted in issues with cost, supply, and wider scale application of these systems. Within this chapter we explore manufacturing processes that can be used for the production of liposomal adjuvants, and we outline new manufacturing methods can that offer fast, scalable, and cost-effective production of liposomal adjuvants.

Original languageEnglish
Title of host publicationVaccine adjuvants
Subtitle of host publicationmethods and protocols
EditorsChristopher B. Fox
Place of PublicationNew York (US)
PublisherSpringer
Pages127-144
Number of pages18
ISBN (Electronic)978-1-4939-6445-1
ISBN (Print)978-1-4939-6443-7
DOIs
Publication statusPublished - 8 Oct 2016

Publication series

NameMethods in Molecular Biology
PublisherSpringer
Volume1494
ISSN (Print)1064-3745

Keywords

  • adjuvants
  • delivery system
  • liposomes
  • manufacturing
  • preparation
  • subunit vaccine

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  • In silico adjuvant design and validation

    Davies, M. N., Pere, H., Bosschem, I., Haesebrouck, F., Flahou, B., Tartour, E., Flower, D. R., Tough, D. F. & Bayry, J., 8 Oct 2016, Vaccine adjuvants: methods and protocols. Fox, C. B. (ed.). New York (US): Springer, p. 107-125 19 p. (Methods in Molecular Biology; vol. 1494).

    Research output: Chapter in Book/Report/Conference proceedingChapter

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