Mapping of polycrystalline films of biological fluids utilizing the Jones-matrix formalism

Vladimir A. Ushenko, Alexander V. Dubolazov, Leonid Y. Pidkamin, Michael Yu Sakchnovsky, Anna B. Bodnar, Yuriy A. Ushenko, Alexander G. Ushenko, Alexander Bykov, Igor Meglinski

Research output: Contribution to journalArticle

Abstract

Utilizing a polarized light approach, we reconstruct the spatial distribution of birefringence and optical activity in polycrystalline films of biological fluids. The Jones-matrix formalism is used for an accessible quantitative description of these types of optical anisotropy. We demonstrate that differentiation of polycrystalline films of biological fluids can be performed based on a statistical analysis of the distribution of rotation angles and phase shifts associated with the optical activity and birefringence, respectively. Finally, practical operational characteristics, such as sensitivity, specificity and accuracy of the Jones-matrix reconstruction of optical anisotropy, were identified with special emphasis on biomedical application, specifically for differentiation of bile films taken from healthy donors and from patients with cholelithiasis.

Original languageEnglish
Article number025602
JournalLaser Physics
Volume28
Issue number2
DOIs
Publication statusPublished - 8 Jan 2018

Keywords

  • Jones-matrix formalism
  • polarimetric imaging
  • polarimetry
  • polarization
  • scattering
  • tissue characterization

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    Ushenko, V. A., Dubolazov, A. V., Pidkamin, L. Y., Sakchnovsky, M. Y., Bodnar, A. B., Ushenko, Y. A., Ushenko, A. G., Bykov, A., & Meglinski, I. (2018). Mapping of polycrystalline films of biological fluids utilizing the Jones-matrix formalism. Laser Physics, 28(2), [025602]. https://doi.org/10.1088/1555-6611/aa8cd9