Mapping of polycrystalline films of biological fluids utilizing the Jones-matrix formalism

Vladimir A. Ushenko, Alexander V. Dubolazov, Leonid Y. Pidkamin, Michael Yu Sakchnovsky, Anna B. Bodnar, Yuriy A. Ushenko, Alexander G. Ushenko, Alexander Bykov, Igor Meglinski

Research output: Contribution to journalArticle

Abstract

Utilizing a polarized light approach, we reconstruct the spatial distribution of birefringence and optical activity in polycrystalline films of biological fluids. The Jones-matrix formalism is used for an accessible quantitative description of these types of optical anisotropy. We demonstrate that differentiation of polycrystalline films of biological fluids can be performed based on a statistical analysis of the distribution of rotation angles and phase shifts associated with the optical activity and birefringence, respectively. Finally, practical operational characteristics, such as sensitivity, specificity and accuracy of the Jones-matrix reconstruction of optical anisotropy, were identified with special emphasis on biomedical application, specifically for differentiation of bile films taken from healthy donors and from patients with cholelithiasis.

Original languageEnglish
Article number025602
JournalLaser Physics
Volume28
Issue number2
DOIs
Publication statusPublished - 8 Jan 2018

Fingerprint

Optical anisotropy
optical activity
formalism
Birefringence
Fluids
birefringence
fluids
matrices
anisotropy
Light polarization
Phase shift
statistical analysis
polarized light
Spatial distribution
Statistical methods
spatial distribution
phase shift
sensitivity
shift

Keywords

  • Jones-matrix formalism
  • polarimetric imaging
  • polarimetry
  • polarization
  • scattering
  • tissue characterization

Cite this

Ushenko, V. A., Dubolazov, A. V., Pidkamin, L. Y., Sakchnovsky, M. Y., Bodnar, A. B., Ushenko, Y. A., ... Meglinski, I. (2018). Mapping of polycrystalline films of biological fluids utilizing the Jones-matrix formalism. Laser Physics, 28(2), [025602]. https://doi.org/10.1088/1555-6611/aa8cd9
Ushenko, Vladimir A. ; Dubolazov, Alexander V. ; Pidkamin, Leonid Y. ; Sakchnovsky, Michael Yu ; Bodnar, Anna B. ; Ushenko, Yuriy A. ; Ushenko, Alexander G. ; Bykov, Alexander ; Meglinski, Igor. / Mapping of polycrystalline films of biological fluids utilizing the Jones-matrix formalism. In: Laser Physics. 2018 ; Vol. 28, No. 2.
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Ushenko, VA, Dubolazov, AV, Pidkamin, LY, Sakchnovsky, MY, Bodnar, AB, Ushenko, YA, Ushenko, AG, Bykov, A & Meglinski, I 2018, 'Mapping of polycrystalline films of biological fluids utilizing the Jones-matrix formalism', Laser Physics, vol. 28, no. 2, 025602. https://doi.org/10.1088/1555-6611/aa8cd9

Mapping of polycrystalline films of biological fluids utilizing the Jones-matrix formalism. / Ushenko, Vladimir A.; Dubolazov, Alexander V.; Pidkamin, Leonid Y.; Sakchnovsky, Michael Yu; Bodnar, Anna B.; Ushenko, Yuriy A.; Ushenko, Alexander G.; Bykov, Alexander; Meglinski, Igor.

In: Laser Physics, Vol. 28, No. 2, 025602, 08.01.2018.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Mapping of polycrystalline films of biological fluids utilizing the Jones-matrix formalism

AU - Ushenko, Vladimir A.

AU - Dubolazov, Alexander V.

AU - Pidkamin, Leonid Y.

AU - Sakchnovsky, Michael Yu

AU - Bodnar, Anna B.

AU - Ushenko, Yuriy A.

AU - Ushenko, Alexander G.

AU - Bykov, Alexander

AU - Meglinski, Igor

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Y1 - 2018/1/8

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AB - Utilizing a polarized light approach, we reconstruct the spatial distribution of birefringence and optical activity in polycrystalline films of biological fluids. The Jones-matrix formalism is used for an accessible quantitative description of these types of optical anisotropy. We demonstrate that differentiation of polycrystalline films of biological fluids can be performed based on a statistical analysis of the distribution of rotation angles and phase shifts associated with the optical activity and birefringence, respectively. Finally, practical operational characteristics, such as sensitivity, specificity and accuracy of the Jones-matrix reconstruction of optical anisotropy, were identified with special emphasis on biomedical application, specifically for differentiation of bile films taken from healthy donors and from patients with cholelithiasis.

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KW - polarimetric imaging

KW - polarimetry

KW - polarization

KW - scattering

KW - tissue characterization

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Ushenko VA, Dubolazov AV, Pidkamin LY, Sakchnovsky MY, Bodnar AB, Ushenko YA et al. Mapping of polycrystalline films of biological fluids utilizing the Jones-matrix formalism. Laser Physics. 2018 Jan 8;28(2). 025602. https://doi.org/10.1088/1555-6611/aa8cd9