Abstract
Utilizing a polarized light approach, we reconstruct the spatial distribution of birefringence and optical activity in polycrystalline films of biological fluids. The Jones-matrix formalism is used for an accessible quantitative description of these types of optical anisotropy. We demonstrate that differentiation of polycrystalline films of biological fluids can be performed based on a statistical analysis of the distribution of rotation angles and phase shifts associated with the optical activity and birefringence, respectively. Finally, practical operational characteristics, such as sensitivity, specificity and accuracy of the Jones-matrix reconstruction of optical anisotropy, were identified with special emphasis on biomedical application, specifically for differentiation of bile films taken from healthy donors and from patients with cholelithiasis.
| Original language | English |
|---|---|
| Article number | 025602 |
| Journal | Laser Physics |
| Volume | 28 |
| Issue number | 2 |
| DOIs | |
| Publication status | Published - 8 Jan 2018 |
Funding
This work was supported by the Strategic Action funding programme of the ITEE Faculty of the University of Oulu. IM also acknowledges partial support from the MEPhI Academic Excellence Project (Contract No. 02.a03.21.0005) and Russian Science Foundation (Grant No.: 15-14-10008).
Keywords
- Jones-matrix formalism
- polarimetric imaging
- polarimetry
- polarization
- scattering
- tissue characterization