MARK-AGE biomarkers of ageing

Alexander Bürkle*, María Moreno-Villanueva, Jürgen Bernhard, María Blasco, Gerben Zondag, Jan H.J. Hoeijmakers, Olivier Toussaint, Beatrix Grubeck-Loebenstein, Eugenio Mocchegiani, Sebastiano Collino, Efstathios S. Gonos, Ewa Sikora, Daniela Gradinaru, Martijn Dollé, Michel Salmon, Peter Kristensen, Helen R. Griffiths, Claude Libert, Tilman Grune, Nicolle BreusingAndreas Simm, Claudio Franceschi, Miriam Capri, Duncan Talbot, Paola Caiafa, Bertrand Friguet, P. Eline Slagboom, Antti Hervonen, Mikko Hurme, Richard Aspinall

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review


Many candidate biomarkers of human ageing have been proposed in the scientific literature but in all cases their variability in cross-sectional studies is considerable, and therefore no single measurement has proven to serve a useful marker to determine, on its own, biological age. A plausible reason for this is the intrinsic multi-causal and multi-system nature of the ageing process. The recently completed MARK-AGE study was a large-scale integrated project supported by the European Commission. The major aim of this project was to conduct a population study comprising about 3200 subjects in order to identify a set of biomarkers of ageing which, as a combination of parameters with appropriate weighting, would measure biological age better than any marker in isolation.

Original languageEnglish
Pages (from-to)2-12
Number of pages11
JournalMechanisms of Ageing and Development
Early online date24 Mar 2015
Publication statusPublished - Nov 2015

Bibliographical note

© 2015 Z. Published by Elsevier Ireland Ltd. This is an open access article under the CC BY-NC-ND license (

European Commission for financial support through the FP7 large-scale integrating project “European Study to Establish Biomarkers of Human Ageing” (MARK-AGE; grant agreement no.: 200880.


  • ageing biomarkers
  • human studies


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