MARK-AGE biomarkers of ageing

Alexander Bürkle; María Moreno-Villanueva; Jürgen Bernhard; María Blasco; Gerben Zondag; Jan H.J. Hoeijmakers; Olivier Toussaint; Beatrix Grubeck-Loebenstein; Eugenio Mocchegiani; Sebastiano Collino; Efstathios S. Gonos; Ewa Sikora; Daniela Gradinaru; Martijn Dollé; Michel Salmon; Peter Kristensen; Helen R. Griffiths; Claude Libert; Tilman Grune; Nicolle Breusing; Andreas Simm; Claudio Franceschi; Miriam Capri; Duncan Talbot; Paola Caiafa; Bertrand Friguet; P. Eline Slagboom; Antti Hervonen; Mikko Hurme; Richard Aspinall

doi:10.1016/j.mad.2015.03.006

MARK-AGE biomarkers of ageing

Alexander Bürkle^*
, María Moreno-Villanueva
, Jürgen Bernhard
, María Blasco
, Gerben Zondag
, Jan H.J. Hoeijmakers
, Olivier Toussaint
, Beatrix Grubeck-Loebenstein
, Eugenio Mocchegiani
, Sebastiano Collino
, Efstathios S. Gonos
, Ewa Sikora
, Daniela Gradinaru
, Martijn Dollé
, Michel Salmon
, Peter Kristensen
, Helen R. Griffiths
, Claude Libert
, Tilman Grune
, Nicolle Breusing

Andreas Simm, Claudio Franceschi, Miriam Capri, Duncan Talbot, Paola Caiafa, Bertrand Friguet, P. Eline Slagboom, Antti Hervonen, Mikko Hurme, Richard Aspinall

^*Corresponding author for this work

Universität Konstanz
BioTeSys GmbH
Spanish National Cancer Research Centre
DNage BV
Erasmus Universiteit Rotterdam
Université de Namur
Leopold-Franzens-Universität Innsbruck
IRCCS-INRCA
Nestlé Institute of Health Sciences SA
National Hellenic Research Foundation
Polska Akademia Nauk
Universitea de Medicină şi Farmacie "Carol Davila" Bucareşti
Centre for Prevention and Health Services Research
Straticell
Aarhus University
Universiteit Gent
Friedrich-Schiller-Universität Jena
Universität Hohenheim
Universitätsklinikum Halle (Saale)
Università degli Studi di Bologna
Unilever Corporate Research
Università degli Studi di Roma La Sapienza
Sorbonne Universités
Leiden University Medical Centre
Tampereen Yliopisto
Regenerative Medicine Group

Research output: Contribution to journal › Article › peer-review

198 Citations (Scopus)

235 Downloads (Pure)

Abstract

Many candidate biomarkers of human ageing have been proposed in the scientific literature but in all cases their variability in cross-sectional studies is considerable, and therefore no single measurement has proven to serve a useful marker to determine, on its own, biological age. A plausible reason for this is the intrinsic multi-causal and multi-system nature of the ageing process. The recently completed MARK-AGE study was a large-scale integrated project supported by the European Commission. The major aim of this project was to conduct a population study comprising about 3200 subjects in order to identify a set of biomarkers of ageing which, as a combination of parameters with appropriate weighting, would measure biological age better than any marker in isolation.

Original language	English
Pages (from-to)	2-12
Number of pages	11
Journal	Mechanisms of Ageing and Development
Volume	151
Early online date	24 Mar 2015
DOIs	https://doi.org/10.1016/j.mad.2015.03.006
Publication status	Published - Nov 2015

Bibliographical note

© 2015 Z. Published by Elsevier Ireland Ltd. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

European Commission for financial support through the FP7 large-scale integrating project “European Study to Establish Biomarkers of Human Ageing” (MARK-AGE; grant agreement no.: 200880.

Keywords

ageing biomarkers
human studies
MARK-AGE

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10.1016/j.mad.2015.03.006

MARK-AGE biomarkers of ageing
© 2015 Z. Published by Elsevier Ireland Ltd. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
Final published version, 575 KBLicence: CC BY-NC-ND 3.0

Cite this

Bürkle, A., Moreno-Villanueva, M., Bernhard, J., Blasco, M., Zondag, G., Hoeijmakers, J. H. J., Toussaint, O., Grubeck-Loebenstein, B., Mocchegiani, E., Collino, S., Gonos, E. S., Sikora, E., Gradinaru, D., Dollé, M., Salmon, M., Kristensen, P., Griffiths, H. R., Libert, C., Grune, T., ... Aspinall, R. (2015). MARK-AGE biomarkers of ageing. Mechanisms of Ageing and Development, 151, 2-12. https://doi.org/10.1016/j.mad.2015.03.006

@article{7235fb8a22b54c899e89c14d9235bce5,

title = "MARK-AGE biomarkers of ageing",

abstract = "Many candidate biomarkers of human ageing have been proposed in the scientific literature but in all cases their variability in cross-sectional studies is considerable, and therefore no single measurement has proven to serve a useful marker to determine, on its own, biological age. A plausible reason for this is the intrinsic multi-causal and multi-system nature of the ageing process. The recently completed MARK-AGE study was a large-scale integrated project supported by the European Commission. The major aim of this project was to conduct a population study comprising about 3200 subjects in order to identify a set of biomarkers of ageing which, as a combination of parameters with appropriate weighting, would measure biological age better than any marker in isolation.",

keywords = "ageing biomarkers, human studies, MARK-AGE",

author = "Alexander B{\"u}rkle and Mar{\'i}a Moreno-Villanueva and J{\"u}rgen Bernhard and Mar{\'i}a Blasco and Gerben Zondag and Hoeijmakers, \{Jan H.J.\} and Olivier Toussaint and Beatrix Grubeck-Loebenstein and Eugenio Mocchegiani and Sebastiano Collino and Gonos, \{Efstathios S.\} and Ewa Sikora and Daniela Gradinaru and Martijn Doll{\'e} and Michel Salmon and Peter Kristensen and Griffiths, \{Helen R.\} and Claude Libert and Tilman Grune and Nicolle Breusing and Andreas Simm and Claudio Franceschi and Miriam Capri and Duncan Talbot and Paola Caiafa and Bertrand Friguet and Slagboom, \{P. Eline\} and Antti Hervonen and Mikko Hurme and Richard Aspinall",

note = "{\textcopyright} 2015 Z. Published by Elsevier Ireland Ltd. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). European Commission for financial support through the FP7 large-scale integrating project “European Study to Establish Biomarkers of Human Ageing” (MARK-AGE; grant agreement no.: 200880.",

year = "2015",

month = nov,

doi = "10.1016/j.mad.2015.03.006",

language = "English",

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Bürkle, A, Moreno-Villanueva, M, Bernhard, J, Blasco, M, Zondag, G, Hoeijmakers, JHJ, Toussaint, O, Grubeck-Loebenstein, B, Mocchegiani, E, Collino, S, Gonos, ES, Sikora, E, Gradinaru, D, Dollé, M, Salmon, M, Kristensen, P, Griffiths, HR, Libert, C, Grune, T, Breusing, N, Simm, A, Franceschi, C, Capri, M, Talbot, D, Caiafa, P, Friguet, B, Slagboom, PE, Hervonen, A, Hurme, M & Aspinall, R 2015, 'MARK-AGE biomarkers of ageing', Mechanisms of Ageing and Development, vol. 151, pp. 2-12. https://doi.org/10.1016/j.mad.2015.03.006

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T1 - MARK-AGE biomarkers of ageing

AU - Bürkle, Alexander

AU - Moreno-Villanueva, María

AU - Bernhard, Jürgen

AU - Blasco, María

AU - Zondag, Gerben

AU - Hoeijmakers, Jan H.J.

AU - Toussaint, Olivier

AU - Grubeck-Loebenstein, Beatrix

AU - Mocchegiani, Eugenio

AU - Collino, Sebastiano

AU - Gonos, Efstathios S.

AU - Sikora, Ewa

AU - Gradinaru, Daniela

AU - Dollé, Martijn

AU - Salmon, Michel

AU - Kristensen, Peter

AU - Griffiths, Helen R.

AU - Libert, Claude

AU - Grune, Tilman

AU - Breusing, Nicolle

AU - Simm, Andreas

AU - Franceschi, Claudio

AU - Capri, Miriam

AU - Talbot, Duncan

AU - Caiafa, Paola

AU - Friguet, Bertrand

AU - Slagboom, P. Eline

AU - Hervonen, Antti

AU - Hurme, Mikko

AU - Aspinall, Richard

N1 - © 2015 Z. Published by Elsevier Ireland Ltd. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). European Commission for financial support through the FP7 large-scale integrating project “European Study to Establish Biomarkers of Human Ageing” (MARK-AGE; grant agreement no.: 200880.

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N2 - Many candidate biomarkers of human ageing have been proposed in the scientific literature but in all cases their variability in cross-sectional studies is considerable, and therefore no single measurement has proven to serve a useful marker to determine, on its own, biological age. A plausible reason for this is the intrinsic multi-causal and multi-system nature of the ageing process. The recently completed MARK-AGE study was a large-scale integrated project supported by the European Commission. The major aim of this project was to conduct a population study comprising about 3200 subjects in order to identify a set of biomarkers of ageing which, as a combination of parameters with appropriate weighting, would measure biological age better than any marker in isolation.

AB - Many candidate biomarkers of human ageing have been proposed in the scientific literature but in all cases their variability in cross-sectional studies is considerable, and therefore no single measurement has proven to serve a useful marker to determine, on its own, biological age. A plausible reason for this is the intrinsic multi-causal and multi-system nature of the ageing process. The recently completed MARK-AGE study was a large-scale integrated project supported by the European Commission. The major aim of this project was to conduct a population study comprising about 3200 subjects in order to identify a set of biomarkers of ageing which, as a combination of parameters with appropriate weighting, would measure biological age better than any marker in isolation.

KW - ageing biomarkers

KW - human studies

KW - MARK-AGE

UR - https://www.scopus.com/pages/publications/84941698753

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DO - 10.1016/j.mad.2015.03.006

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SN - 1872-6216

VL - 151

SP - 2

EP - 12

JO - Mechanisms of Ageing and Development

JF - Mechanisms of Ageing and Development

ER -

MARK-AGE biomarkers of ageing

Abstract

Bibliographical note

Keywords

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