Material and structures for gastrointestinal stents

Richard A. Rothwell, Mark S. Pridham, Gareth A. Thomson

Research output: Chapter in Book/Report/Conference proceedingConference publication

Abstract

Stents are used to counteract and relieve in-vivo duct or vessel obstructions. The purpose of the current study is to select a biocompatible, biodegradable material for use in the manufacture of stents to counteract anastomotic leakage following gastrointestinal surgery. Chitosan a biocompatible, biodegradable environmentally friendly natural polysaccharide was blended with polycaprolactone, a versatile synthetic polymer. This material was fabricated in the form of sheets by moulding and curing blends of chitosan / polycaprolactone. The tensile strength of chitosan and chitosan / polycaprolactone blends were investigated. These tensile tests were carried out on chitosan and chitosan / polycaprolactone blends of 50/50, 40/60, 30/70 and 20/80 wt/wt %, cured in 5% sodium hydroxide. The chitosan / polycaprolactone blends were then formed into stents. The sheet mouldings were wound around a stainless steel stent former while fixing the layers together with un-cured chitosan / polycaprolactone blend and subsequently curing the layers together with sodium hydroxide, producing the stent shape. This research concluded that the chitosan / polycaprolactone blends of various compositions show a wide range of strain at failure and mechanical strengths. Furthermore the fabrication of the chitosan / polycaprolactone stents show that the blends can be formed into thin films wound into tubular stent structures. This indicates that the material blends are suitable materials for the further development of biodegradable stents designed to counteract gastrointestinal leakage.

Original languageEnglish
Title of host publicationWorld Congress on Medical Physics and Biomedical Engineering, September 7 - 12, 2009, Munich, Germany
Subtitle of host publicationdiagnostic and therapeutic instrumentation, clinical engineering
EditorsOlaf Dössel, Wolfgang C. Schlegel
Place of PublicationBerlin (DE)
PublisherSpringer
Pages46-49
Number of pages4
ISBN (Electronic)978-3-642-03900-3
ISBN (Print)978-3-642-03899-0
DOIs
Publication statusPublished - 1 Dec 2009
EventWorld Congress on Medical Physics and Biomedical Engineering - Munich, Germany
Duration: 7 Sep 200912 Sep 2009

Publication series

NameIFMBE Proceedings
PublisherSpringer
Number10
Volume25
ISSN (Print)1680-0737
ISSN (Electronic)1433-9277

Congress

CongressWorld Congress on Medical Physics and Biomedical Engineering
CountryGermany
CityMunich
Period7/09/0912/09/09
OtherImage Processing, Biosignal Processing, Modelling and Simulation, Biomechanics

Keywords

  • anastomotic leakage
  • bioabsorbable
  • chitosan
  • polycaprolactone
  • stent

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  • Research Output

    • 2 Conference publication

    A smart generic micro-drilling tool applied in cochleostomy

    Brett, P. N., Taylor, R. P., Du, X., Proops, D., Griffiths, M. V. & Coulson, C., 1 Dec 2009, World Congress on Medical Physics and Biomedical Engineering, September 7 - 12, 2009, Munich, Germany: diagnostic and therapeutic instrumentation, clinical engineering. Dössel, O. & Schlegel, W. C. (eds.). Berlin (DE): Springer, p. 314-316 3 p. (IFMBE Proceedings; vol. 25, no. 10).

    Research output: Chapter in Book/Report/Conference proceedingConference publication

  • Disinfection of surgical materials using photo-activated tolonium chloride

    Thomson, G. A., Mackay, R., Pridham, M. S. & Liu, Y. L., 1 Dec 2009, World Congress on Medical Physics and Biomedical Engineering, September 7 - 12, 2009, Munich, Germany: diagnostic and therapeutic instrumentation, clinical engineering. Dössel, O. & Schlegel, W. C. (eds.). Berlin (DE): Springer, p. 133-136 4 p. (IFMBE Proceedings; vol. 25, no. 10).

    Research output: Chapter in Book/Report/Conference proceedingConference publication

  • Cite this

    Rothwell, R. A., Pridham, M. S., & Thomson, G. A. (2009). Material and structures for gastrointestinal stents. In O. Dössel, & W. C. Schlegel (Eds.), World Congress on Medical Physics and Biomedical Engineering, September 7 - 12, 2009, Munich, Germany: diagnostic and therapeutic instrumentation, clinical engineering (pp. 46-49). (IFMBE Proceedings; Vol. 25, No. 10). Springer. https://doi.org/10.1007/978-3-642-03900-3_14