Matrix-assisted diffusion-ordered spectroscopy

Robert Evans, Iain J. Day

Research output: Contribution to journalReview article

Abstract

Diffusion NMR is a potentially routine tool in the analysis of mixtures, from industrial and synthetic outputs to natural products. However, the technique struggles to resolve species of similar size. Matrix-assisted DOSY offers a flexible approach to resolving such ambiguities on the basis of the chemical structures involved and on their interactions with a larger co-solute or matrix. The use of chromatographic supports, surfactants and polymers, in particular, is illustrated. The resolution of a wide range of different analyte mixtures, on the basis of differences in chemical structure and in stereochemistry, is demonstrated.

LanguageEnglish
Pages47010-47022
Number of pages13
JournalRSC advances
Volume6
Issue number52
Early online date26 Apr 2016
DOIs
Publication statusE-pub ahead of print - 26 Apr 2016

Fingerprint

Spectroscopy
Stereochemistry
Biological Products
Surface-Active Agents
Polymers
Surface active agents
Nuclear magnetic resonance

Bibliographical note

Funding: EPSRC (EP/H025367/1)

Cite this

Evans, Robert ; Day, Iain J. / Matrix-assisted diffusion-ordered spectroscopy. In: RSC advances. 2016 ; Vol. 6, No. 52. pp. 47010-47022.
@article{05175e1ca4bd4b72947008e16bfe8140,
title = "Matrix-assisted diffusion-ordered spectroscopy",
abstract = "Diffusion NMR is a potentially routine tool in the analysis of mixtures, from industrial and synthetic outputs to natural products. However, the technique struggles to resolve species of similar size. Matrix-assisted DOSY offers a flexible approach to resolving such ambiguities on the basis of the chemical structures involved and on their interactions with a larger co-solute or matrix. The use of chromatographic supports, surfactants and polymers, in particular, is illustrated. The resolution of a wide range of different analyte mixtures, on the basis of differences in chemical structure and in stereochemistry, is demonstrated.",
author = "Robert Evans and Day, {Iain J.}",
note = "Funding: EPSRC (EP/H025367/1)",
year = "2016",
month = "4",
day = "26",
doi = "10.1039/c6ra05380g",
language = "English",
volume = "6",
pages = "47010--47022",
journal = "RSC advances",
issn = "2046-2069",
publisher = "Royal Society of Chemistry",
number = "52",

}

Matrix-assisted diffusion-ordered spectroscopy. / Evans, Robert; Day, Iain J.

In: RSC advances, Vol. 6, No. 52, 26.04.2016, p. 47010-47022.

Research output: Contribution to journalReview article

TY - JOUR

T1 - Matrix-assisted diffusion-ordered spectroscopy

AU - Evans, Robert

AU - Day, Iain J.

N1 - Funding: EPSRC (EP/H025367/1)

PY - 2016/4/26

Y1 - 2016/4/26

N2 - Diffusion NMR is a potentially routine tool in the analysis of mixtures, from industrial and synthetic outputs to natural products. However, the technique struggles to resolve species of similar size. Matrix-assisted DOSY offers a flexible approach to resolving such ambiguities on the basis of the chemical structures involved and on their interactions with a larger co-solute or matrix. The use of chromatographic supports, surfactants and polymers, in particular, is illustrated. The resolution of a wide range of different analyte mixtures, on the basis of differences in chemical structure and in stereochemistry, is demonstrated.

AB - Diffusion NMR is a potentially routine tool in the analysis of mixtures, from industrial and synthetic outputs to natural products. However, the technique struggles to resolve species of similar size. Matrix-assisted DOSY offers a flexible approach to resolving such ambiguities on the basis of the chemical structures involved and on their interactions with a larger co-solute or matrix. The use of chromatographic supports, surfactants and polymers, in particular, is illustrated. The resolution of a wide range of different analyte mixtures, on the basis of differences in chemical structure and in stereochemistry, is demonstrated.

UR - http://www.scopus.com/inward/record.url?scp=84971247619&partnerID=8YFLogxK

U2 - 10.1039/c6ra05380g

DO - 10.1039/c6ra05380g

M3 - Review article

VL - 6

SP - 47010

EP - 47022

JO - RSC advances

T2 - RSC advances

JF - RSC advances

SN - 2046-2069

IS - 52

ER -