Mechanical effects of left ventricular midwall fibrosis in non-ischemic cardiomyopathy

Robin J. Taylor, Fraz Umar, Erica L S Lin, Amar Ahmed, William E. Moody, Wojciech Mazur, Berthold Stegemann, Jonathan N. Townend, Richard P. Steeds, Francisco Leyva*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review


Background: Left ventricular (LV) mid-wall fibrosis (MWF), which occurs in about a quarter of patients with non-ischemic cardiomyopathy (NICM), is associated with high risk of pump failure. The mid LV wall is the site of circumferential myocardial fibers. We sought to determine the effect of MWF on LV myocardial mechanics. Methods: Patients with NICM (n = 116; age: 62.8 ± 13.2 years; 67 % male) underwent late gadolinium enhancement cardiovascular magnetic resonance (CMR) and were categorized according to the presence (+) or absence (-) of MWF. Feature tracking (FT) CMR was used to assess myocardial deformation. Results: Despite a similar LVEF (24.3 vs 27.5 %, p = 0.20), patients with MWF (32 [24 %]) had lower global circumferential strain (εcc: -6.6 % vs -9.4 %, P = 0.004), but similar longitudinal (εll: -7.6 % vs. -9.4 %, p = 0.053) and radial (εrr: 14.6 % vs. 17.8 % p = 0.18) strain. Compared with - MWF, + MWF was associated with reduced LV systolic, circumferential strain rate (-0.38 ± 0.1 vs -0.56 ± 0.3 s-1, p = 0.005) and peak LV twist (4.65 vs. 6.31°, p = 0.004), as well as rigid LV body rotation (64 % vs 28 %, P cc: 0.34 vs. 0.46 s-1; DSRll: 0.38 vs. 0.50s-1; DSRrr: -0.55 vs. -0.75 s-1; all p

Original languageEnglish
Article number221
JournalJournal of Cardiovascular Magnetic Resonance
Issue number1
Publication statusPublished - 5 Jan 2016

Bibliographical note

Copyright: 2016 Taylor et al. Open Access - This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (, which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver ( applies to the data made available in this article, unless otherwise stated.

Funding: Medtronic Inc.


  • Cardiovascular magnetic resonance
  • Feature-tracking
  • Heart failure
  • Mid-wall fibrosis
  • Myocardial deformation
  • Non ischemic dilated cardiomyopathy
  • Torsion


Dive into the research topics of 'Mechanical effects of left ventricular midwall fibrosis in non-ischemic cardiomyopathy'. Together they form a unique fingerprint.

Cite this