Mechanisms governing the reactivation-dependent destabilization of memories and their role in extinction

Charlotte R. Flavell; Elliot A. Lambert; Boyer D. Winters; Timothy W. Bredy

doi:10.3389/fnbeh.2013.00214

Mechanisms governing the reactivation-dependent destabilization of memories and their role in extinction

Charlotte R. Flavell, Elliot A. Lambert, Boyer D. Winters, Timothy W. Bredy

Research output: Contribution to journal › Article › peer-review

Abstract

The extinction of learned associations has traditionally been considered to involve new learning, which competes with the original memory for control over behavior. However, a recent resurgence of interest in reactivation-dependent amnesia has revealed that the retrieval of fear-related memory (with what is essentially a brief extinction session) can result in its destabilization. This review discusses some of the cellular and molecular mechanisms that are involved in the destabilization of a memory following its reactivation and/or extinction, and investigates the evidence that extinction may involve both new learning as well as a partial destabilization-induced erasure of the original memory trace.

Original language	English
Article number	214
Journal	Frontiers in Behavioral Neuroscience
Volume	7
DOIs	https://doi.org/10.3389/fnbeh.2013.00214
Publication status	Published - 26 Dec 2013

Bibliographical note

© 2013 Flavell, Lambert, Winters and Bredy. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

Access to Document

10.3389/fnbeh.2013.00214Licence: CC BY 3.0

Mechanisms governing the reactivation-dependent destabilization of memoriesFinal published version, 559 KBLicence: CC BY 3.0

Cite this

@article{a512e45721c94f9d9a8fa54a5f49c61c,

title = "Mechanisms governing the reactivation-dependent destabilization of memories and their role in extinction",

abstract = "The extinction of learned associations has traditionally been considered to involve new learning, which competes with the original memory for control over behavior. However, a recent resurgence of interest in reactivation-dependent amnesia has revealed that the retrieval of fear-related memory (with what is essentially a brief extinction session) can result in its destabilization. This review discusses some of the cellular and molecular mechanisms that are involved in the destabilization of a memory following its reactivation and/or extinction, and investigates the evidence that extinction may involve both new learning as well as a partial destabilization-induced erasure of the original memory trace.",

author = "Flavell, {Charlotte R.} and Lambert, {Elliot A.} and Winters, {Boyer D.} and Bredy, {Timothy W.}",

note = "{\textcopyright} 2013 Flavell, Lambert, Winters and Bredy. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.",

year = "2013",

month = dec,

day = "26",

doi = "10.3389/fnbeh.2013.00214",

language = "English",

volume = "7",

journal = "Frontiers in Behavioral Neuroscience",

issn = "1662-5153",

publisher = "Frontiers Media S.A.",

}

TY - JOUR

T1 - Mechanisms governing the reactivation-dependent destabilization of memories and their role in extinction

AU - Flavell, Charlotte R.

AU - Lambert, Elliot A.

AU - Winters, Boyer D.

AU - Bredy, Timothy W.

N1 - © 2013 Flavell, Lambert, Winters and Bredy. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

PY - 2013/12/26

Y1 - 2013/12/26

N2 - The extinction of learned associations has traditionally been considered to involve new learning, which competes with the original memory for control over behavior. However, a recent resurgence of interest in reactivation-dependent amnesia has revealed that the retrieval of fear-related memory (with what is essentially a brief extinction session) can result in its destabilization. This review discusses some of the cellular and molecular mechanisms that are involved in the destabilization of a memory following its reactivation and/or extinction, and investigates the evidence that extinction may involve both new learning as well as a partial destabilization-induced erasure of the original memory trace.

AB - The extinction of learned associations has traditionally been considered to involve new learning, which competes with the original memory for control over behavior. However, a recent resurgence of interest in reactivation-dependent amnesia has revealed that the retrieval of fear-related memory (with what is essentially a brief extinction session) can result in its destabilization. This review discusses some of the cellular and molecular mechanisms that are involved in the destabilization of a memory following its reactivation and/or extinction, and investigates the evidence that extinction may involve both new learning as well as a partial destabilization-induced erasure of the original memory trace.

UR - http://journal.frontiersin.org/article/10.3389/fnbeh.2013.00214/abstract

U2 - 10.3389/fnbeh.2013.00214

DO - 10.3389/fnbeh.2013.00214

M3 - Article

C2 - 24421762

SN - 1662-5153

VL - 7

JO - Frontiers in Behavioral Neuroscience

JF - Frontiers in Behavioral Neuroscience

M1 - 214

ER -

Mechanisms governing the reactivation-dependent destabilization of memories and their role in extinction

Abstract

Bibliographical note

Access to Document

Other files and links

Fingerprint

Cite this