Mechanisms governing the reactivation-dependent destabilization of memories and their role in extinction

Charlotte R. Flavell, Elliot A. Lambert, Boyer D. Winters, Timothy W. Bredy

Research output: Contribution to journalArticle

Abstract

The extinction of learned associations has traditionally been considered to involve new learning, which competes with the original memory for control over behavior. However, a recent resurgence of interest in reactivation-dependent amnesia has revealed that the retrieval of fear-related memory (with what is essentially a brief extinction session) can result in its destabilization. This review discusses some of the cellular and molecular mechanisms that are involved in the destabilization of a memory following its reactivation and/or extinction, and investigates the evidence that extinction may involve both new learning as well as a partial destabilization-induced erasure of the original memory trace.
Original languageEnglish
Article number214
JournalFrontiers in Behavioral Neuroscience
Volume7
DOIs
Publication statusPublished - 26 Dec 2013

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Learning
Behavior Control
Amnesia
Fear
Psychological Extinction

Bibliographical note

© 2013 Flavell, Lambert, Winters and Bredy. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Flavell, C. R., Lambert, E. A., Winters, B. D., & Bredy, T. W. (2013). Mechanisms governing the reactivation-dependent destabilization of memories and their role in extinction. Frontiers in Behavioral Neuroscience, 7, [214]. https://doi.org/10.3389/fnbeh.2013.00214
Flavell, Charlotte R. ; Lambert, Elliot A. ; Winters, Boyer D. ; Bredy, Timothy W. / Mechanisms governing the reactivation-dependent destabilization of memories and their role in extinction. In: Frontiers in Behavioral Neuroscience. 2013 ; Vol. 7.
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Mechanisms governing the reactivation-dependent destabilization of memories and their role in extinction. / Flavell, Charlotte R.; Lambert, Elliot A.; Winters, Boyer D.; Bredy, Timothy W.

In: Frontiers in Behavioral Neuroscience, Vol. 7, 214, 26.12.2013.

Research output: Contribution to journalArticle

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