Meningeal Lymphatic Pathway of Brain Clearing From the Blood After Haemorrhagic Injuries

O. Semyachkina-glushkovskaya, N. Navolokin, A. Shirokov, A. Terskov, A. Khorovodov, A. Mamedova, M. Klimova, E. Rafailov, J. Kurths

Research output: Chapter in Book/Published conference outputChapter


This seems to be the time to gain new knowledge about the meningeal lymphatic system and a deeper understanding of its anatomy and physiology. Although it is known that the meningeal lymphatics present in the layers of the brain, limited information is available about the role of this system in brain function. Here, for the first time we clearly demonstrate that the meningeal lymphatic pathway is involved in brain clearing from the blood after intracranial hemorrhage associated with hypoxia and forms a connective bridge between interstitial, cerebral spinal fluid and peripheral lymphatics. We also show that the development of methods to stimulate meningeal lymph flow after hemorrhagic evidence in the brain might be a neuroprotective strategy for effective recovery of the brain after a cerebrovascular catastrophe.
Original languageEnglish
Title of host publicationOxygen Transport to Tissue XLI. Advances in Experimental Medicine and Biology
EditorsP.D. Ryu, J. LaManna, D. Harrison, S.S. Lee
Number of pages6
Publication statusPublished - 1 Jan 2020

Publication series

NameAdvances in Experimental Medicine and Biology
ISSN (Print)0065-2598
ISSN (Electronic)2214-8019

Bibliographical note

© Springer Nature Switzerland AG 2020.


  • Blood-brain barrier
  • Brain drainage and clearance
  • Hypoxia
  • Intracranial hemorrhages
  • Lymphatic system


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