Methodology for development of a physiological model incorporating CYP3A and P-glycoprotein for the prediction of intestinal drug absorption

Keyphrases

• Cytochrome P450 3A (CYP3A) 100%
• P-glycoprotein (P-gp) 100%
• Physiological Model 100%
• Intestinal Absorption 100%
• Cytochrome aa3 80%
• Enterocyte 40%
• Small Intestine 40%
• Metabolic Clearance 40%
• Metabolism 20%
• Highly Sensitive 20%
• Cytochrome P450 (CYP450) 20%
• Intestinal Epithelial Cells 20%
• Active Efflux 20%
• In Vitro Data 20%
• Drug Metabolism 20%
• Drug Distribution 20%
• Drug Permeation 20%
• PH Modifier 20%
• Orally Administered 20%
• Distal Intestine 20%
• Geometric Variation 20%
• Efficient Absorption 20%
• Passive Permeability 20%
• Physiologically-based Pharmacokinetic Model 20%
• P-glycoprotein Efflux 20%
• G-value 20%
• Efflux Ratio 20%

Biochemistry, Genetics and Molecular Biology

• CYP3A 100%
• P-Glycoprotein 100%
• Drug Absorption 100%
• Cytochrome 83%
• Absorption 33%
• Small Intestine 33%
• Metabolic Clearance 33%
• Metabolic Pathway 16%
• Pharmacokinetics 16%
• Drug Penetration 16%
• Drug Distribution 16%
• Efflux Ratio 16%
• Drug Metabolism 16%

Pharmacology, Toxicology and Pharmaceutical Science

• P-Glycoprotein 100%
• CYP3A 100%
• Intestinal Drug Absorption 100%
• Cytochrome 83%
• Effusion 50%
• Pharmacokinetics 16%
• Drug Distribution 16%
• Drug Metabolism 16%