Microparticle surface layering through dry coating: impact of moisture content and process parameters on the properties of orally disintegrating tablets

Hamad Alyami, Jasdip Koner, Eman Z. Dahmash, James Bowen, David Terry, Afzal R. Mohammed

Research output: Contribution to journalArticle

Abstract

OBJECTIVES: The aim of this study was to investigate the influence of process parameters during dry coating on particle and dosage form properties upon varying the surface adsorbed moisture of microcrystalline cellulose (MCC), a model filler/binder for orally disintegrating tablets (ODTs).

METHODS: The moisture content of MCC was optimised using the spray water method and analysed using thermogravimetric analysis. Microproperty/macroproperty assessment was investigated using atomic force microscopy, nano-indentation, scanning electron microscopy, tablet hardness and disintegration testing.

KEY FINDINGS: The results showed that MCC demonstrated its best flowability at a moisture content of 11.2% w/w when compared to control, comprising of 3.9% w/w moisture. The use of the composite powder coating process (without air) resulted in up to 80% increase in tablet hardness, when compared to the control. The study also demonstrated that surface adsorbed moisture can be displaced upon addition of excipients during dry processing circumventing the need for particle drying before tabletting.

CONCLUSIONS: It was concluded that MCC with a moisture content of 11% w/w provides a good balance between powder flowability and favourable ODT characteristics.

LanguageEnglish
JournalJournal of Pharmacy and Pharmacology
VolumeEarly view
Early online date2 Oct 2016
DOIs
Publication statusE-pub ahead of print - 2 Oct 2016

Fingerprint

Tablets
Hardness
Powders
Atomic Force Microscopy
Excipients
Dosage Forms
Electron Scanning Microscopy
Air
microcrystalline cellulose
Water

Bibliographical note

This is the peer reviewed version of the following article: Alyami, H., Koner, J., Dahmash, E. Z., Bowen, J., Terry, D., & Mohammed, A. R. (2016). Microparticle surface layering through dry coating: impact of moisture content and process parameters on the properties of orally disintegrating tablets. Journal of Pharmacy and Pharmacology, Early view, which has been published in final form at http://dx.doi.org/10.1111/jphp.12623. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving.

Keywords

  • composite
  • disintegration
  • flowability
  • hardness
  • nano-indentation

Cite this

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abstract = "OBJECTIVES: The aim of this study was to investigate the influence of process parameters during dry coating on particle and dosage form properties upon varying the surface adsorbed moisture of microcrystalline cellulose (MCC), a model filler/binder for orally disintegrating tablets (ODTs).METHODS: The moisture content of MCC was optimised using the spray water method and analysed using thermogravimetric analysis. Microproperty/macroproperty assessment was investigated using atomic force microscopy, nano-indentation, scanning electron microscopy, tablet hardness and disintegration testing.KEY FINDINGS: The results showed that MCC demonstrated its best flowability at a moisture content of 11.2{\%} w/w when compared to control, comprising of 3.9{\%} w/w moisture. The use of the composite powder coating process (without air) resulted in up to 80{\%} increase in tablet hardness, when compared to the control. The study also demonstrated that surface adsorbed moisture can be displaced upon addition of excipients during dry processing circumventing the need for particle drying before tabletting.CONCLUSIONS: It was concluded that MCC with a moisture content of 11{\%} w/w provides a good balance between powder flowability and favourable ODT characteristics.",
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Microparticle surface layering through dry coating : impact of moisture content and process parameters on the properties of orally disintegrating tablets. / Alyami, Hamad; Koner, Jasdip; Dahmash, Eman Z.; Bowen, James; Terry, David; Mohammed, Afzal R.

In: Journal of Pharmacy and Pharmacology, Vol. Early view, 02.10.2016.

Research output: Contribution to journalArticle

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T2 - Journal of Pharmacy and Pharmacology

AU - Alyami, Hamad

AU - Koner, Jasdip

AU - Dahmash, Eman Z.

AU - Bowen, James

AU - Terry, David

AU - Mohammed, Afzal R.

N1 - This is the peer reviewed version of the following article: Alyami, H., Koner, J., Dahmash, E. Z., Bowen, J., Terry, D., & Mohammed, A. R. (2016). Microparticle surface layering through dry coating: impact of moisture content and process parameters on the properties of orally disintegrating tablets. Journal of Pharmacy and Pharmacology, Early view, which has been published in final form at http://dx.doi.org/10.1111/jphp.12623. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving.

PY - 2016/10/2

Y1 - 2016/10/2

N2 - OBJECTIVES: The aim of this study was to investigate the influence of process parameters during dry coating on particle and dosage form properties upon varying the surface adsorbed moisture of microcrystalline cellulose (MCC), a model filler/binder for orally disintegrating tablets (ODTs).METHODS: The moisture content of MCC was optimised using the spray water method and analysed using thermogravimetric analysis. Microproperty/macroproperty assessment was investigated using atomic force microscopy, nano-indentation, scanning electron microscopy, tablet hardness and disintegration testing.KEY FINDINGS: The results showed that MCC demonstrated its best flowability at a moisture content of 11.2% w/w when compared to control, comprising of 3.9% w/w moisture. The use of the composite powder coating process (without air) resulted in up to 80% increase in tablet hardness, when compared to the control. The study also demonstrated that surface adsorbed moisture can be displaced upon addition of excipients during dry processing circumventing the need for particle drying before tabletting.CONCLUSIONS: It was concluded that MCC with a moisture content of 11% w/w provides a good balance between powder flowability and favourable ODT characteristics.

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