Microporous polycaprolactone matrices for controlled drug delivery

H. I. Chang*, Y. Perrie, A. G A Coombes

*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

The incorporation and release of a lipophilic steroid (progesterone) from microporous polycaprolactone matrices (MPM), inorder to illustrate the capacity for controlled drug delivery from precipitation cast materials, was reported. It was shown that precipitation casting of MPM occurs by extraction of solvent across a semi-permeable membrane formed at the solution/methanol interface. It was observed that the density of MPM ranged from 0.18-0.33 g/cm3 and increased with increasing concentration of the PCL solution. It was concluded that the drug delivery from precipitation cast, PCL matrices may be controlled by variation of processing parameters such as initial drug loading and the matrix density.

Original languageEnglish
Title of host publicationTransactions - 7th World Biomaterials Congress
Publication statusPublished - 1 Dec 2004
EventTransactions - 7th World Biomaterials Congress - Sydney, United Kingdom
Duration: 17 May 200421 May 2004

Conference

ConferenceTransactions - 7th World Biomaterials Congress
CountryUnited Kingdom
CitySydney
Period17/05/0421/05/04

Fingerprint

Controlled drug delivery
Polycaprolactone
Drug delivery
Casting
Methanol
Membranes
Processing

Cite this

Chang, H. I., Perrie, Y., & Coombes, A. G. A. (2004). Microporous polycaprolactone matrices for controlled drug delivery. In Transactions - 7th World Biomaterials Congress
Chang, H. I. ; Perrie, Y. ; Coombes, A. G A. / Microporous polycaprolactone matrices for controlled drug delivery. Transactions - 7th World Biomaterials Congress. 2004.
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Chang, HI, Perrie, Y & Coombes, AGA 2004, Microporous polycaprolactone matrices for controlled drug delivery. in Transactions - 7th World Biomaterials Congress. Transactions - 7th World Biomaterials Congress, Sydney, United Kingdom, 17/05/04.

Microporous polycaprolactone matrices for controlled drug delivery. / Chang, H. I.; Perrie, Y.; Coombes, A. G A.

Transactions - 7th World Biomaterials Congress. 2004.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

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T1 - Microporous polycaprolactone matrices for controlled drug delivery

AU - Chang, H. I.

AU - Perrie, Y.

AU - Coombes, A. G A

PY - 2004/12/1

Y1 - 2004/12/1

N2 - The incorporation and release of a lipophilic steroid (progesterone) from microporous polycaprolactone matrices (MPM), inorder to illustrate the capacity for controlled drug delivery from precipitation cast materials, was reported. It was shown that precipitation casting of MPM occurs by extraction of solvent across a semi-permeable membrane formed at the solution/methanol interface. It was observed that the density of MPM ranged from 0.18-0.33 g/cm3 and increased with increasing concentration of the PCL solution. It was concluded that the drug delivery from precipitation cast, PCL matrices may be controlled by variation of processing parameters such as initial drug loading and the matrix density.

AB - The incorporation and release of a lipophilic steroid (progesterone) from microporous polycaprolactone matrices (MPM), inorder to illustrate the capacity for controlled drug delivery from precipitation cast materials, was reported. It was shown that precipitation casting of MPM occurs by extraction of solvent across a semi-permeable membrane formed at the solution/methanol interface. It was observed that the density of MPM ranged from 0.18-0.33 g/cm3 and increased with increasing concentration of the PCL solution. It was concluded that the drug delivery from precipitation cast, PCL matrices may be controlled by variation of processing parameters such as initial drug loading and the matrix density.

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BT - Transactions - 7th World Biomaterials Congress

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Chang HI, Perrie Y, Coombes AGA. Microporous polycaprolactone matrices for controlled drug delivery. In Transactions - 7th World Biomaterials Congress. 2004