The incorporation and release of a lipophilic steroid (progesterone) from microporous polycaprolactone matrices (MPM), inorder to illustrate the capacity for controlled drug delivery from precipitation cast materials, was reported. It was shown that precipitation casting of MPM occurs by extraction of solvent across a semi-permeable membrane formed at the solution/methanol interface. It was observed that the density of MPM ranged from 0.18-0.33 g/cm3 and increased with increasing concentration of the PCL solution. It was concluded that the drug delivery from precipitation cast, PCL matrices may be controlled by variation of processing parameters such as initial drug loading and the matrix density.
|Title of host publication||Transactions - 7th World Biomaterials Congress|
|Publication status||Published - 1 Dec 2004|
|Event||Transactions - 7th World Biomaterials Congress - Sydney, United Kingdom|
Duration: 17 May 2004 → 21 May 2004
|Conference||Transactions - 7th World Biomaterials Congress|
|Period||17/05/04 → 21/05/04|