Microporous polycaprolactone matrices for drug delivery and tissue engineering: the release behaviour of bioactives having extremes of aqueous solubility

H.-I. Chang, Y. Wang, Y. Perrie, A.G.A. Coombes

Research output: Contribution to journalArticle

Abstract

Microporous polycaprolactone (PCL) matrices loaded with hydrophobic steroidal drugs or a hydrophilic drug - pilocarpine hydrochloride - were produced by precipitation casting using solutions of PCL in acetone. The efficiency of steroid incorporation in the final matrix (progesterone (56 %) testosterone (46 %) dexamethasone (80 %)) depended on the nature of the drug initially co-dissolved in the PCL solution. Approximately 90 % w/w of the initial load of progesterone, 85 % testosterone and 50 % dexamethasone was released from the matrices in PBS at 37°C over 8 days. Pilocarpine hydrochloride (PH)-loaded PCL matrices, prepared by dispersion of powder in PCL solution, released 70-90 % of the PH content over 12 days in PBS. Application of the Higuchi model revealed that the kinetics of steroid and PH release were consistent with a Fickian diffusion mechanism with corresponding diffusion coefficients of 5.8 × 10-9 (progesterone), 3.9 × 10 -9 (testosterone), 7.1 × 10-10 (dexamethasone) and 22 × 10-8 cm2/s (pilocarpine hydrochloride). The formulation techniques described are expected to be useful for production of implantable, insertable and topical devices for sustained delivery of a range of bioactive molecules of interest in drug delivery and tissue engineering.

LanguageEnglish
Pages207-212
Number of pages6
JournalJournal of Drug Delivery Science and Technology
Volume20
Issue number3
DOIs
Publication statusPublished - 2010

Fingerprint

Pilocarpine
Tissue Engineering
Solubility
Dexamethasone
Progesterone
Testosterone
Pharmaceutical Preparations
Steroids
Acetone
Powders
polycaprolactone
Equipment and Supplies

Keywords

  • Matrix device
  • Microporous
  • Ocular delivery
  • Pilocarpine
  • Polycaprolactone
  • Steroids
  • Tissue engineering

Cite this

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abstract = "Microporous polycaprolactone (PCL) matrices loaded with hydrophobic steroidal drugs or a hydrophilic drug - pilocarpine hydrochloride - were produced by precipitation casting using solutions of PCL in acetone. The efficiency of steroid incorporation in the final matrix (progesterone (56 {\%}) testosterone (46 {\%}) dexamethasone (80 {\%})) depended on the nature of the drug initially co-dissolved in the PCL solution. Approximately 90 {\%} w/w of the initial load of progesterone, 85 {\%} testosterone and 50 {\%} dexamethasone was released from the matrices in PBS at 37°C over 8 days. Pilocarpine hydrochloride (PH)-loaded PCL matrices, prepared by dispersion of powder in PCL solution, released 70-90 {\%} of the PH content over 12 days in PBS. Application of the Higuchi model revealed that the kinetics of steroid and PH release were consistent with a Fickian diffusion mechanism with corresponding diffusion coefficients of 5.8 × 10-9 (progesterone), 3.9 × 10 -9 (testosterone), 7.1 × 10-10 (dexamethasone) and 22 × 10-8 cm2/s (pilocarpine hydrochloride). The formulation techniques described are expected to be useful for production of implantable, insertable and topical devices for sustained delivery of a range of bioactive molecules of interest in drug delivery and tissue engineering.",
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Microporous polycaprolactone matrices for drug delivery and tissue engineering : the release behaviour of bioactives having extremes of aqueous solubility. / Chang, H.-I.; Wang, Y.; Perrie, Y.; Coombes, A.G.A.

In: Journal of Drug Delivery Science and Technology, Vol. 20, No. 3, 2010, p. 207-212.

Research output: Contribution to journalArticle

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