Microvillar dynamic in renal tubular epithelial cells mediated by insulin/PLCγ signal pathway

Lida Wu, Tongri Liu, Yuchun Gu*

*Corresponding author for this work

Research output: Contribution to journalArticle

Abstract

Significant cellular morphology changes in renal tubules were observed in diabetes patients and animal models. However, the interaction between insulin and tubular epithelial cells microvillar structure remains obscure. To understand microvillar dynamics, we used Scanning Ion Conductance Microscope to visualize microvillar in the living cell. Here, we found two layers of microvilli on the tubular epithelial cell surface: short compact microvilli and netlike long microvilli. Insulin treatment could increase microvilli length and density. This process was mediated by the PI3K/PLCγ signaling pathway, other than the PI3K/Arp2/3 signal pathway. In conclusion, our findings present a novel insulin signaling transduction mechanism, which contributes to understanding renal tubular epithelial cell microvilli dynamic regulation.

Original languageEnglish
JournalBiochemical and Biophysical Research Communications
Early online date31 Oct 2020
DOIs
Publication statusE-pub ahead of print - 31 Oct 2020

Keywords

  • Insulin signal transduction
  • Microvilli formation
  • Renal tubular epithelial cells

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