miRNAs in post-ischaemic angiogenesis and vascular remodelling

Jaimy Saif, Costanza Emanueli

Research output: Contribution to journalReview article

Abstract

miRNAs are highly conserved non-coding RNA molecules that negatively control gene expression by binding to target mRNAs promoting their degradation. A multitude of miRNAs have been reported to be involved in angiogenesis and vascular remodelling. In the present review, we aim to describe the effect of miRNAs in post-ischaemic repair. First, we describe the miRNAs reported in ischaemic diseases and in angiogenesis. Then we examine their capacity to modulate the behaviour of stem and progenitor cells which could be utilized for vascular repair. And finally we discuss the potential of miRNAs as new clinical biomarkers and therapeutic targets.

Original languageEnglish
Pages (from-to)1629-1636
Number of pages8
JournalBiochemical Society Transactions
Volume42
Issue number6
DOIs
Publication statusPublished - 17 Nov 2014

Fingerprint

MicroRNAs
Repair
Stem Cells
Untranslated RNA
Biomarkers
Gene expression
Blood Vessels
Vascular Remodeling
Gene Expression
Degradation
Messenger RNA
Molecules
Therapeutics

Keywords

  • Biomarkers
  • Humans
  • Ischemia/genetics
  • MicroRNAs/genetics
  • Neovascularization, Pathologic/genetics
  • Vascular Remodeling/genetics

Cite this

Saif, Jaimy ; Emanueli, Costanza. / miRNAs in post-ischaemic angiogenesis and vascular remodelling. In: Biochemical Society Transactions. 2014 ; Vol. 42, No. 6. pp. 1629-1636.
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miRNAs in post-ischaemic angiogenesis and vascular remodelling. / Saif, Jaimy; Emanueli, Costanza.

In: Biochemical Society Transactions, Vol. 42, No. 6, 17.11.2014, p. 1629-1636.

Research output: Contribution to journalReview article

TY - JOUR

T1 - miRNAs in post-ischaemic angiogenesis and vascular remodelling

AU - Saif, Jaimy

AU - Emanueli, Costanza

PY - 2014/11/17

Y1 - 2014/11/17

N2 - miRNAs are highly conserved non-coding RNA molecules that negatively control gene expression by binding to target mRNAs promoting their degradation. A multitude of miRNAs have been reported to be involved in angiogenesis and vascular remodelling. In the present review, we aim to describe the effect of miRNAs in post-ischaemic repair. First, we describe the miRNAs reported in ischaemic diseases and in angiogenesis. Then we examine their capacity to modulate the behaviour of stem and progenitor cells which could be utilized for vascular repair. And finally we discuss the potential of miRNAs as new clinical biomarkers and therapeutic targets.

AB - miRNAs are highly conserved non-coding RNA molecules that negatively control gene expression by binding to target mRNAs promoting their degradation. A multitude of miRNAs have been reported to be involved in angiogenesis and vascular remodelling. In the present review, we aim to describe the effect of miRNAs in post-ischaemic repair. First, we describe the miRNAs reported in ischaemic diseases and in angiogenesis. Then we examine their capacity to modulate the behaviour of stem and progenitor cells which could be utilized for vascular repair. And finally we discuss the potential of miRNAs as new clinical biomarkers and therapeutic targets.

KW - Biomarkers

KW - Humans

KW - Ischemia/genetics

KW - MicroRNAs/genetics

KW - Neovascularization, Pathologic/genetics

KW - Vascular Remodeling/genetics

UR - http://www.biochemsoctrans.org/content/42/6/1629.article-info

U2 - 10.1042/BST20140263

DO - 10.1042/BST20140263

M3 - Review article

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VL - 42

SP - 1629

EP - 1636

JO - Biochemical Society Transactions

JF - Biochemical Society Transactions

SN - 0300-5127

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