miRNAs in post-ischaemic angiogenesis and vascular remodelling

Jaimy Saif, Costanza Emanueli

Research output: Contribution to journalReview article

Abstract

miRNAs are highly conserved non-coding RNA molecules that negatively control gene expression by binding to target mRNAs promoting their degradation. A multitude of miRNAs have been reported to be involved in angiogenesis and vascular remodelling. In the present review, we aim to describe the effect of miRNAs in post-ischaemic repair. First, we describe the miRNAs reported in ischaemic diseases and in angiogenesis. Then we examine their capacity to modulate the behaviour of stem and progenitor cells which could be utilized for vascular repair. And finally we discuss the potential of miRNAs as new clinical biomarkers and therapeutic targets.

Original languageEnglish
Pages (from-to)1629-1636
Number of pages8
JournalBiochemical Society Transactions
Volume42
Issue number6
DOIs
Publication statusPublished - 17 Nov 2014

Keywords

  • Biomarkers
  • Humans
  • Ischemia/genetics
  • MicroRNAs/genetics
  • Neovascularization, Pathologic/genetics
  • Vascular Remodeling/genetics

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