Colistin has a physical mechanism of action. It damages membranes with a lethal effect and does not inhibit enzymes or sophisticated cellular systems. Colistin has a self-promoted uptake mechanism and ultimately targets the cytoplasmic membrane. It is bactericidal at low concentrations. Resistance rates are very low, although resistance is possible.
|Title of host publication||International Congress and Symposium Series - Royal Society of Medicine|
|Place of Publication||London (UK)|
|Number of pages||7|
|Publication status||Published - 27 Aug 2004|
|Name||International Congress and Symposium Series of the Royal Society of Medicine|
|Publisher||Royal Society of Medicine Press Ltd|
- resistance mechanisms