Mode of action of colistin - resistance mechanisms

Peter A. Lambert

Mode of action of colistin - resistance mechanisms

^*Corresponding author for this work

Research output: Chapter in Book/Published conference output › Conference publication

Abstract

Colistin has a physical mechanism of action. It damages membranes with a lethal effect and does not inhibit enzymes or sophisticated cellular systems. Colistin has a self-promoted uptake mechanism and ultimately targets the cytoplasmic membrane. It is bactericidal at low concentrations. Resistance rates are very low, although resistance is possible.

Original language	English
Title of host publication	International Congress and Symposium Series - Royal Society of Medicine
Editors	D. Geddes
Place of Publication	London (UK)
Publisher	RSM Press
Pages	2-8
Number of pages	7
Volume	258
ISBN (Print)	9781853155895
Publication status	Published - 27 Aug 2004

Publication series

Name	International Congress and Symposium Series of the Royal Society of Medicine
Publisher	Royal Society of Medicine Press Ltd
ISSN (Print)	0142-2367

Keywords

colistin
resistance mechanisms

Cite this

@inproceedings{6792ae481f1a4c098f72f9c52d101589,

title = "Mode of action of colistin - resistance mechanisms",

abstract = "Colistin has a physical mechanism of action. It damages membranes with a lethal effect and does not inhibit enzymes or sophisticated cellular systems. Colistin has a self-promoted uptake mechanism and ultimately targets the cytoplasmic membrane. It is bactericidal at low concentrations. Resistance rates are very low, although resistance is possible.",

keywords = "colistin, resistance mechanisms",

author = "Lambert, {Peter A.}",

year = "2004",

month = aug,

day = "27",

language = "English",

isbn = "9781853155895",

volume = "258",

series = "International Congress and Symposium Series of the Royal Society of Medicine",

publisher = "RSM Press",

pages = "2--8",

editor = "D. Geddes",

booktitle = "International Congress and Symposium Series - Royal Society of Medicine",

}

Mode of action of colistin - resistance mechanisms. / Lambert, Peter A.
International Congress and Symposium Series - Royal Society of Medicine. ed. / D. Geddes. Vol. 258 London (UK): RSM Press, 2004. p. 2-8 (International Congress and Symposium Series of the Royal Society of Medicine).

Research output: Chapter in Book/Published conference output › Conference publication

TY - GEN

T1 - Mode of action of colistin - resistance mechanisms

AU - Lambert, Peter A.

PY - 2004/8/27

Y1 - 2004/8/27

N2 - Colistin has a physical mechanism of action. It damages membranes with a lethal effect and does not inhibit enzymes or sophisticated cellular systems. Colistin has a self-promoted uptake mechanism and ultimately targets the cytoplasmic membrane. It is bactericidal at low concentrations. Resistance rates are very low, although resistance is possible.

AB - Colistin has a physical mechanism of action. It damages membranes with a lethal effect and does not inhibit enzymes or sophisticated cellular systems. Colistin has a self-promoted uptake mechanism and ultimately targets the cytoplasmic membrane. It is bactericidal at low concentrations. Resistance rates are very low, although resistance is possible.

KW - colistin

KW - resistance mechanisms

UR - http://www.scopus.com/inward/record.url?scp=77950033926&partnerID=8YFLogxK

UR - http://www.rsmpress.co.uk/bkgeddes.htm

M3 - Conference publication

SN - 9781853155895

VL - 258

T3 - International Congress and Symposium Series of the Royal Society of Medicine

SP - 2

EP - 8

BT - International Congress and Symposium Series - Royal Society of Medicine

A2 - Geddes, D.

PB - RSM Press

CY - London (UK)

ER -

Mode of action of colistin - resistance mechanisms

Abstract

Publication series

Keywords

Other files and links

Fingerprint

Cite this