Modeling anthropometric indices in relation to 10-year (2002-2012) incidence of cardiovascular disease, among apparently healthy individuals: the ATTICA study

Theodosios D. Filippatos, Ioannis Kyrou, Ekavi N. Georgousopoulou, Christina Chrysohoou, Georgia-Maria Kouli, Constantine Tsigos, Dimitrios Tousoulis, Christodoulos Stefanadis, Christos Pitsavos, Demosthenes B. Panagiotakos*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

Abstract

Aims: Body fat accumulation is implicated in the development of cardiovascular disease (CVD). Our objective was to explore potential associations between anthropometric indices and the 10-year CVD incidence in Greek adults without previous CVD.
Methods: During 2001–2, we enrolled 3042 adults without CVD from the general population of Attica, Greece. In 2011–2, the 10-year study follow-up was performed, recording the CVD incidence in 1958 participants with baseline body mass index (BMI) ≥18.5 kg/m2.
Results: The study 10-year CVD incidence was 15.8%, exhibiting a gradual increase according to the baseline body mass index (BMI) category. Baseline BMI ≥30 kg/m2 was related with significantly higher 10-year CVD risk compared to BMI <25 kg/m2, even after adjustment for age and other known CVD risk factors. Baseline BMI, waist circumference, waist-to-hip ratio, waist-to-height ratio and waist-to-hip-to-height ratio were independently associated with the 10-year CVD risk in multi-adjusted models. Gender-specific analyses showed that these associations were more evident in men compared to women, with baseline BMI exhibiting an independent association with the 10-year CVD incidence in men.
Conclusions: Our results indicate that even simple anthropometric indices exhibit independent associations with CVD risk in a representative sample of the Greek general population without previous CVD.
Original languageEnglish
JournalDiabetes & Metabolic Syndrome: Clinical Research & Reviews
Volumein press
Early online date3 Jun 2017
DOIs
Publication statusE-pub ahead of print - 3 Jun 2017

Bibliographical note

© 2017, Elsevier. Licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International http://creativecommons.org/licenses/by-nc-nd/4.0/

Keywords

  • anthropometric indices
  • cardiovascular disease
  • body mass index
  • waist circumference
  • obesity

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