TY - JOUR
T1 - Modeling effect of GABAergic current in a basal ganglia computational model
AU - Njap, Felix
AU - Claussen, Jens Christian
AU - Moser, Andreas
AU - Hofmann, Ulrich G.
PY - 2012/8/1
Y1 - 2012/8/1
N2 - Electrical high frequency stimulation (HFS) of deep brain regions is amethod shown to be clinically effective in different types of movement and neurological disorders. In order to shed light on its mode of action a computational model of the basal ganglia network coupled the HFS as injection current into the cells of the subthalamic nucleus (STN). Its overall increased activity rendered a faithful transmission of sensorimotor input through thalamo-cortical relay cells possible. Our contribution uses this model by Rubin and Terman (J Comput Neurosci, 16, 211-223, 2004) as a starting point and integrates recent findings on the importance of the extracellular concentrations of the inhibiting neuro-transmitter GABA. We are able to show in this computational study that besides electrical stimulation a high concentration of GABA and its resulting conductivity in STN cells is able to re-establish faithful thalamocortical relaying, which otherwise broke down in the simulated parkinsonian state.
AB - Electrical high frequency stimulation (HFS) of deep brain regions is amethod shown to be clinically effective in different types of movement and neurological disorders. In order to shed light on its mode of action a computational model of the basal ganglia network coupled the HFS as injection current into the cells of the subthalamic nucleus (STN). Its overall increased activity rendered a faithful transmission of sensorimotor input through thalamo-cortical relay cells possible. Our contribution uses this model by Rubin and Terman (J Comput Neurosci, 16, 211-223, 2004) as a starting point and integrates recent findings on the importance of the extracellular concentrations of the inhibiting neuro-transmitter GABA. We are able to show in this computational study that besides electrical stimulation a high concentration of GABA and its resulting conductivity in STN cells is able to re-establish faithful thalamocortical relaying, which otherwise broke down in the simulated parkinsonian state.
KW - Computational model
KW - Deep brain stimulation
KW - Parkinsonian condition
KW - Synaptic conductances
KW - Y-Aminobutyric acid
UR - http://www.scopus.com/inward/record.url?scp=84865788592&partnerID=8YFLogxK
UR - https://link.springer.com/article/10.1007%2Fs11571-012-9203-3
U2 - 10.1007/s11571-012-9203-3
DO - 10.1007/s11571-012-9203-3
M3 - Article
AN - SCOPUS:84865788592
SN - 1871-4080
VL - 6
SP - 333
EP - 341
JO - Cognitive Neurodynamics
JF - Cognitive Neurodynamics
IS - 4
ER -