Modelling G-protein-coupled receptors for drug design

DR Flower

Research output: Contribution to journalArticle

Abstract

The G-protein coupled receptors form a large and diverse multi-gene superfamily with many important physiological functions. As such, they have become important targets in pharmaceutical research. Molecular modelling and site-directed mutagenesis have played an important role in our increasing understanding of the structural basis of drug action at these receptors. Aspects of this understanding, how these techniques can be used within a drug-design programme, and remaining challenges for the future are reviewed..
Original languageEnglish
Pages (from-to)207-234
Number of pages28
JournalBBA - Reviews on Biomembranes
Volume1422
Issue number3
DOIs
Publication statusUnpublished - 16 Nov 1999

Fingerprint

Drug Design
G-Protein-Coupled Receptors
Site-Directed Mutagenesis
Pharmaceutical Preparations
Genes
Pharmaceutical Research

Keywords

  • G-Protein-coupled receptor
  • drug design
  • mutagenesis
  • molecular modeling
  • agonist
  • antagonist

Cite this

Flower, DR. / Modelling G-protein-coupled receptors for drug design. In: BBA - Reviews on Biomembranes. 1999 ; Vol. 1422, No. 3. pp. 207-234.
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Modelling G-protein-coupled receptors for drug design. / Flower, DR.

In: BBA - Reviews on Biomembranes, Vol. 1422, No. 3, 16.11.1999, p. 207-234.

Research output: Contribution to journalArticle

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