Modelling G-protein-coupled receptors for drug design

DR Flower

Research output: Contribution to journalArticle


The G-protein coupled receptors form a large and diverse multi-gene superfamily with many important physiological functions. As such, they have become important targets in pharmaceutical research. Molecular modelling and site-directed mutagenesis have played an important role in our increasing understanding of the structural basis of drug action at these receptors. Aspects of this understanding, how these techniques can be used within a drug-design programme, and remaining challenges for the future are reviewed..
Original languageEnglish
Pages (from-to)207-234
Number of pages28
JournalBBA - Reviews on Biomembranes
Issue number3
Publication statusUnpublished - 16 Nov 1999


  • G-Protein-coupled receptor
  • drug design
  • mutagenesis
  • molecular modeling
  • agonist
  • antagonist


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