Modified release of beclometasone dipropionate from chitosan-basedd spray-dried respirable powders

Tristan P. Learoyd, Jane L. Burrows, Eddie French, Peter C. Seville

Research output: Contribution to journalArticle

Abstract

Dry powders for inhalation were prepared by spray drying a 30% v/v aqueous ethanol formulation containing beclometasone dipropionate (BDP), lactose, leucine and chitosan (low, medium or high molecular weight (MW), or combinations thereof). Following physical characterisation of the powders, the aerosolisation and dissolution properties of the powders were investigated using Multi-Stage Liquid Impinger and USP II dissolution apparatus, respectively. The powders were highly dispersible, with emitted doses in excess of 90% of loaded powder aerosolised from a Spinhaler dry powder inhaler. The fine particle fraction (FPF) was observed to decrease, whereas the time for 100% drug release increased, with increasing chitosan MW. For example, the low MW formulation exhibited an FPF of 64% and a 100% dissolution time of 2 h, whereas the high MW formulation demonstrated an FPF of 54% and a dissolution time of 12 h. These powders would be anticipated to deposit predominately in the lower regions of the lung following inhalation, and then undergo delayed rather than instantaneous drug release, offering the potential to reduce dosing frequency and improve patient compliance. (c) 2008 Elsevier B.V. All rights reserved.
Original languageEnglish
Pages (from-to)231-238
Number of pages8
JournalPowder Technology
Volume187
Issue number3
DOIs
Publication statusPublished - 20 Nov 2008

Keywords

  • Spray-drying
  • Leucine
  • Modified release
  • Inhalation
  • Aerosolisation
  • Chitosan

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