Molecular pathways leading to cancer cachexia

Michael J. Tisdale*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review


Loss of body weight in cancer patients strongly influences morbidity and mortality. Recent studies have suggested that both tumor and host factors play a major role in tissue catabolism in cachexia, leading to upregulation of degradative pathways in both skeletal muscle and adipose tissue. ©2005 Int. Union Physiol. Sci./Am. Physiol. Soc.

Original languageEnglish
Pages (from-to)340-348
Number of pages9
Issue number5
Publication statusPublished - Oct 2005


  • body weight
  • cancer patients
  • morbidity
  • mortality
  • tumor
  • host factors
  • tissue catabolism
  • cachexia
  • upregulation
  • skeletal muscle
  • adipose tissue


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