Molecularly imprinted polymers in the drug discovery process

Daniel L. Rathbone

doi:10.1016/j.addr.2005.07.017

Molecularly imprinted polymers in the drug discovery process

Daniel L. Rathbone^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

Abstract

Since molecularly imprinted polymers (MIPs) are designed to have a memory for their molecular templates it is easy to draw parallels with the affinity between biological receptors and their substrates. Could MIPs take the place of natural receptors in the selection of potential drug molecules from synthetic compound libraries? To answer that question this review discusses the results of MIP studies which attempt to emulate natural receptors. In addition the possible use of MIPs to guide a compound library synthesis towards a desired biological activity is highlighted. © 2005 Elsevier B.V. All rights reserved.

Original language	English
Pages (from-to)	1854-1874
Number of pages	21
Journal	Advanced Drug Delivery Reviews
Volume	57
Issue number	12
DOIs	https://doi.org/10.1016/j.addr.2005.07.017
Publication status	Published - 4 Dec 2005

Keywords

combinatorial chemistry
composite template
cross-reactivity
molecular imprinting
multiple templates
receptor mimics

Access to Document

10.1016/j.addr.2005.07.017

Cite this

@article{3b8738ec238443239b79d6d67262aa09,

title = "Molecularly imprinted polymers in the drug discovery process",

abstract = "Since molecularly imprinted polymers (MIPs) are designed to have a memory for their molecular templates it is easy to draw parallels with the affinity between biological receptors and their substrates. Could MIPs take the place of natural receptors in the selection of potential drug molecules from synthetic compound libraries? To answer that question this review discusses the results of MIP studies which attempt to emulate natural receptors. In addition the possible use of MIPs to guide a compound library synthesis towards a desired biological activity is highlighted. {\textcopyright} 2005 Elsevier B.V. All rights reserved.",

keywords = "combinatorial chemistry, composite template, cross-reactivity, molecular imprinting, multiple templates, receptor mimics",

author = "Rathbone, {Daniel L.}",

year = "2005",

month = dec,

day = "4",

doi = "10.1016/j.addr.2005.07.017",

language = "English",

volume = "57",

pages = "1854--1874",

journal = "Advanced Drug Delivery Reviews",

issn = "0169-409X",

publisher = "Elsevier",

number = "12",

}

TY - JOUR

T1 - Molecularly imprinted polymers in the drug discovery process

AU - Rathbone, Daniel L.

PY - 2005/12/4

Y1 - 2005/12/4

N2 - Since molecularly imprinted polymers (MIPs) are designed to have a memory for their molecular templates it is easy to draw parallels with the affinity between biological receptors and their substrates. Could MIPs take the place of natural receptors in the selection of potential drug molecules from synthetic compound libraries? To answer that question this review discusses the results of MIP studies which attempt to emulate natural receptors. In addition the possible use of MIPs to guide a compound library synthesis towards a desired biological activity is highlighted. © 2005 Elsevier B.V. All rights reserved.

AB - Since molecularly imprinted polymers (MIPs) are designed to have a memory for their molecular templates it is easy to draw parallels with the affinity between biological receptors and their substrates. Could MIPs take the place of natural receptors in the selection of potential drug molecules from synthetic compound libraries? To answer that question this review discusses the results of MIP studies which attempt to emulate natural receptors. In addition the possible use of MIPs to guide a compound library synthesis towards a desired biological activity is highlighted. © 2005 Elsevier B.V. All rights reserved.

KW - combinatorial chemistry

KW - composite template

KW - cross-reactivity

KW - molecular imprinting

KW - multiple templates

KW - receptor mimics

UR - http://www.scopus.com/inward/record.url?scp=27844444267&partnerID=8YFLogxK

UR - https://www.sciencedirect.com/science/article/pii/S0169409X05001559?via%3Dihub

U2 - 10.1016/j.addr.2005.07.017

DO - 10.1016/j.addr.2005.07.017

M3 - Article

C2 - 16226828

SN - 0169-409X

VL - 57

SP - 1854

EP - 1874

JO - Advanced Drug Delivery Reviews

JF - Advanced Drug Delivery Reviews

IS - 12

ER -

Molecularly imprinted polymers in the drug discovery process

Abstract

Keywords

Access to Document

Other files and links

Fingerprint

Cite this