Molecularly imprinted polymers in the drug discovery process

Daniel L. Rathbone*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review


Since molecularly imprinted polymers (MIPs) are designed to have a memory for their molecular templates it is easy to draw parallels with the affinity between biological receptors and their substrates. Could MIPs take the place of natural receptors in the selection of potential drug molecules from synthetic compound libraries? To answer that question this review discusses the results of MIP studies which attempt to emulate natural receptors. In addition the possible use of MIPs to guide a compound library synthesis towards a desired biological activity is highlighted. © 2005 Elsevier B.V. All rights reserved.

Original languageEnglish
Pages (from-to)1854-1874
Number of pages21
JournalAdvanced Drug Delivery Reviews
Issue number12
Publication statusPublished - 4 Dec 2005


  • combinatorial chemistry
  • composite template
  • cross-reactivity
  • molecular imprinting
  • multiple templates
  • receptor mimics


Dive into the research topics of 'Molecularly imprinted polymers in the drug discovery process'. Together they form a unique fingerprint.

Cite this